Screening of herbal extracts against multi-drug resistant Acinetobacter baumannii

Phytotherapy Research : PTR
Yoko MiyasakiW David Hardy

Abstract

Antibiotic resistance is increasing resulting in a decreasing number of fully active antimicrobial agents available to treat infections with multi-drug resistant (MDR) bacteria. Herbal medicines may offer alternative treatment options. A direct inoculation method simulating the standard disc diffusion assay was developed to determine in vitro antimicrobial activity of sixty herbal extracts against MDR-Acinetobacter baumannii (A. baumannii). Eighteen herbal extracts inhibited MDR-A. baumannii on agar plates, although the magnitude and quality of bacterial inhibition differed considerably among the antibacterial herbal extracts. Next, minimal inhibitory concentration (MIC) of these antibacterial herbal extracts was calculated using a broth microdilution assay. For most herbal extracts, the larger the zone of inhibition on agar plates, the lower the MIC. In general, hetero-resistance on agar plates correlated with higher MIC. The skip well phenomenon was seen with two herbal extracts. In conclusion, 30% of the screened herbal extracts demonstrated in vitro antibacterial activity against MDR-A. baumannii using similar rigorous testing methods as those commonly employed for assessing antimicrobial activity of synthetic antibacterial...Continue Reading

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Citations

Nov 24, 2012·BMC Complementary and Alternative Medicine·Wei-Cheng ChenI-Min Liu
Mar 21, 2015·Jundishapur Journal of Microbiology·Saeide SaeidiMehdi Hassanshahian
Jan 24, 2018·Frontiers in Veterinary Science·Chetan SharmaHarsh Panwar
May 28, 2021·Journal of Experimental Pharmacology·Dessie BelayMastewal Birhan

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