Screening of Latin American plants for antiparasitic activities against malaria, Chagas disease, and leishmaniasis

Pharmaceutical Biology
Angela I CalderónMahabir P Gupta

Abstract

In order to explore rationally the medical potential of the plant biodiversity of the Central and South American region as a source of novel antiparasitic molecules, a multinational Organization of American States (OAS) project, which included the participation of multidisciplinary research centers from Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, was carried out during the period 2001-2004. This project aimed at screening organic plant extracts for antitrypanosomal, antileishmanial and antimalarial activities and subsequently isolating and characterizing bioactive molecules. Plants for antiparasitic screening were selected from a database of ethnomedical uses of Latin American plants (PlanMedia) based on the amount of biological and chemical information available in the literature. We report here the evaluation of 452 extracts from 311 plant species in vitro screens against Plasmodium falciparum, Leishmania mexicana, and Trypanosoma cruzi. Out of 311 species tested, 17 plants (5.4%) showed antiparasitic activities at IC(50) values < or = 10 microg/mL. The most active plants were Acnistus arborescens (L.) Schltdl. (Solanaceae) (leaf, EtOH, IC(50): 4 microg/mL) Monochaetum myrtoideum Naudin (Melasto...Continue Reading

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Citations

Aug 25, 2012·TheScientificWorldJournal·Laura C LaurellaValeria P Sülsen
Jun 15, 2016·Journal of Ethnopharmacology·Idensi Bajin Ba NdobFrancis Bivigou
Dec 27, 2011·Pharmaceutical Biology·Angela I CalderónMahabir P Gupta
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeysson Sánchez-SuárezEricsson Coy-Barrera
Apr 20, 2021·IScience·Andrea SalmJürg Gertsch
May 25, 2021·Journal of Ethnopharmacology·William MillikenEimear Nic Lughadha
Jul 11, 2021·Parasitology Research·Juliana Figueiredo PeixotoLuiz Filipe Gonçalves-Oliveira
Aug 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paola García-Huertas, Nora Cardona-Castro

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