PMID: 696813Sep 1, 1978Paper

Screening of membrane surface charges by divalent cations: an atomic representation

The American Journal of Physiology
J S D'Arrigo

Abstract

To arrive at a clear and atomically realistic representation of the process of ionic screening, a model with the following necessary and justifiable constraints was devised. 1) The minimum internuclear distance (IND) between a negative site on the membrane and a cation screening the site is equal to the sum of the site's "equivalent" radius (rs) + the diameter of a water molecule (approximately 2.8 A) + crystal radius of the cation (rc). 2) The average value for the dielectric constant (D) over IND is given by D approximately 80 ((IND - rs - rc)/IND). When this simple atomic model for ionic screening is employed in conjunction with equilibrium ion-selectivity theory, it is possible to predict quantitatively, from coulombic energy calculations, the secondary stereospecific actions of certain alkaline-earth cations as well as the predominant screening effect of these divalent cations at the surfaces of different types of membranes. The model also successfully predicts the transition from a predominantly screening situation to a predominantly binding situation, which was observed experimentally when negative surface charge density was decreased in nerve.

References

Nov 1, 1975·Journal of Theoretical Biology·A P Nelson, D A McQuarrie
Nov 22, 1976·The Journal of Membrane Biology·J S D'Arrigo
Apr 1, 1975·Journal of Theoretical Biology·A P NelsonD A McQuarrie
Jun 10, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B HilleB I Shapiro
Jul 24, 1975·The Journal of Membrane Biology·J S D'Arrigo
Jan 1, 1974·Progress in Biophysics and Molecular Biology·R H Brown
Jan 1, 1974·Pflügers Archiv : European journal of physiology·W Vogel
Jan 1, 1969·Annual Review of Physiology·J M Diamond, E M Wright
Dec 1, 1971·The Journal of General Physiology·S G McLaughlinG Eisenman
Mar 1, 1969·Biophysical Journal·K S Cole
Mar 1, 1962·Biophysical Journal·G EISENMAN

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Citations

Apr 1, 1988·The Journal of Membrane Biology·M J Kell, L J DeFelice
Mar 4, 2010·Pflügers Archiv : European journal of physiology·Silas SugihartoPeter H Barry
Jan 1, 1983·Biophysics of Structure and Mechanism·P Schlieper, R Steiner
Jun 9, 1981·Biochimica Et Biophysica Acta·P SchlieperR Kaufmann
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Terence Zhi Xiang HongKun Zhou
Jul 21, 1984·Journal of Theoretical Biology·K AiharaY Ikegaya
Jun 2, 2020·The Journal of Physical Chemistry. B·Rajeev Kumar, Murugappan Muthukumar

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