Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay

Journal of Ethnopharmacology
Jofrid RisaA K Jäger

Abstract

A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and ethanol extracts of 43 plants that are traditionally used to treat against epilepsy and convulsions, were tested in the GABAA-benzodiazepine receptor binding assay, where the binding of 3H-Ro 15-1788 (flumazenil) to the benzodiazepine site is measured. The GABAA-benzodiazepine receptor complex is involved in epilepsy and convulsions. Out of the 118 extracts tested, one aqueous and 18 ethanol extracts showed activity. The most active extracts were the ethanolic leaf extracts of Rhus tridentata, Rhus rehmanniana and Hoslundia opposita and the ethanolic corm extract of Hypoxis colchicifolia, which all showed good dose-dependent activity.

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Citations

Nov 5, 2013·Journal of Ethnopharmacology·Bhekumthetho NcubeJohannes Van Staden
May 15, 2012·Pharmacological Reports : PR·Esmaeal TamaddonfardSona Seiednejad-Yamchi
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Sep 9, 2008·Journal of Ethnopharmacology·Mikael Egebjerg PedersenAnna K Jäger
Sep 9, 2008·Journal of Ethnopharmacology·Gary I StaffordAnna K Jäger
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Jan 18, 2005·Journal of Ethnopharmacology·Sam Medhat Salah, Anna Katharina Jäger
Nov 19, 2005·Journal of Ethnopharmacology·Anna K JägerLene Gudiksen
Sep 20, 2005·Journal of Ethnopharmacology·Ann Bygvraa SvenningsenAnna K Jäger
Apr 26, 2005·Journal of Ethnopharmacology·Sam Medhat Salah, Anna Katharina Jäger
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Aug 3, 2018·Biological & Pharmaceutical Bulletin·Ki-Bae HongHyeon-Son Choi
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Oct 28, 2019·Biomolecules & Therapeutics·Tae-Ho KimYi-Sook Jung
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Jul 5, 2017·Biological & Pharmaceutical Bulletin·Hyeon-Son ChoiHyung Joo Suh
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Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki
Jan 6, 2019·Journal of Ethnopharmacology·Emilie AuditeauFarid Boumediene
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Singeun KimHyung Joo Suh
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