Screening of Preselected Libraries Targeting Mycobacterium abscessus for Drug Discovery

Antimicrobial Agents and Chemotherapy
Adrian RichterYossef Av-Gay

Abstract

Mycobacterium abscessus is intrinsically resistant to many antimycobacterial antibiotics, which presents serious problems in therapy. Here, we describe the development of a novel phenotype-based microscopic and computerized imaging drug screening approach. A pilot screen of 568 compounds from two libraries identified 17 hits. Eleven of these compounds are described for the first time as active against M. abscessus The impact of growth media on the activity of these compounds was tested, revealing that cation-adjusted Mueller-Hinton broth (MHII) supports better growth of actively replicating M. abscessus and improves the activity of associated compounds.

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Citations

Mar 13, 2019·International Journal of Mycobacteriology·Beverley Cherie Millar, John Edmund Moore
Sep 18, 2020·Acta Crystallographica. Section E, Crystallographic Communications·Tamira EckhardtRüdiger W Seidel
Aug 21, 2019·Antimicrobial Agents and Chemotherapy·Jakob J MalinJan Rybniker
Apr 8, 2021·Microbiology·Leah Isobella Rankine-WilsonYossef Av-Gay
Jun 17, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Balungile MadikizelaRüdiger W Seidel
May 19, 2021·Antimicrobial Agents and Chemotherapy·Dereje Abate NegatuThomas Dick

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