Screening of some Australian Flacourtiaceae species for in vitro antioxidant, cytotoxic and antimicrobial activity

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
M A MosaddikPeter G Waterman

Abstract

A total of 27 methanol extracts obtained from different plant parts of 10 species of rain forest trees belonging to four genera of the Flacourtiaceae and originating from Australia were investigated. In vitro cytotoxicity was measured by an ATP Lite-M assay method against the mouse P388 lymphocytic leukemia cell line. The total antioxidant activity has been assessed based on scavenging activity of stable ABTS free radicals. The minimum inhibition concentration (MIC) was determined by the dilution method performed in 96 well plates against four different microbes. The leaf extract of Casearia sp. (RB 3051), mature stem extract of Casearia grayi and stem extract of Scolopia braunii were found to have most antioxidant activity (IC50 = 2.9 microg/ml), cytotoxic activity (LC50 = 0.89 microg/ml) and antimicrobial activity against all four different microbes, respectively. The results obtained suggested that among the four genera studied Casearia is the most promising in respect of finding significant antioxidant, cytotoxic and also antimicrobial activity.

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Citations

Sep 17, 2013·Journal of Natural Products·Bo WangXiao-Ning Wang
Jul 21, 2006·Natural Product Research·Clynton W HalsteadPeter G Waterman
Jul 13, 2006·Natural Product Research·M AshikPeter G Waterman
Jul 4, 2013·BMC Complementary and Alternative Medicine·Wangkheirakpam Radhapiyari DeviChingakham B Singh
Sep 12, 2006·Journal of Ethnopharmacology·Michele Luciane DickelMara Rejane Ritter
Oct 6, 2006·FEMS Microbiology Letters·Chulyoung KimChul Soo Shin
Sep 17, 2015·Anais Da Academia Brasileira De Ciências·Éverton José Ferreira de AraújoPaulo Michel Pinheiro Ferreira
Dec 14, 2011·Anais Da Academia Brasileira De Ciências·Paulo Michel P FerreiraClaudia Pessoa
Sep 2, 2017·Journal of Applied Microbiology·S AfraJ Feizy
Dec 14, 2017·Anais Da Academia Brasileira De Ciências·Flaviane G PereiraDavyson L Moreira
May 28, 2011·Journal of Agricultural and Food Chemistry·Shela GorinsteinSimon Trakhtenberg
Mar 28, 2006·Journal of Natural Products·Gordon M CraggStringner S Yang

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