Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus.

TheScientificWorldJournal
Berick Moturi SieberiMathew Piero Ngugi

Abstract

Bacterial infections are responsible for a large number of deaths every year worldwide. On average, 80% of the African population cannot afford conventional drugs. Moreover, many synthetic antibiotics are associated with side effects and progressive increase in antimicrobial resistance. Currently, there is growing interest in discovering new antibacterial agents from ethnomedicinal plants. About 60% of the population living in developing countries depends on herbal drugs for healthcare needs. This study involved the screening of Centella asiatica commonly used by herbal medicine practitioners in Kisii County to treat symptoms related to bacterial infections. Standard bioassay methods were applied throughout the study. They included preliminary screening of dichloromethane: methanolic extract of Centella asiatica against human pathogenic bacteria including Salmonella typhi ATCC 19430, Escherichia coli ATCC 25922, Shigella sonnei ATCC 25931, Bacillus subtilis ATCC 21332, and Staphylococcus aureus ATCC 25923 using agar disc diffusion, broth microdilution method, and time-kill kinetics with tetracycline as a positive control. Phytochemical screening was carried out to determine the different classes of compounds in the crude extrac...Continue Reading

References

Aug 1, 1984·Antimicrobial Agents and Chemotherapy·C J ShanholtzerD N Gerding
Apr 9, 1998·Journal of Ethnopharmacology·W FabryR Ansorg
Oct 6, 1998·Critical Reviews in Food Science and Nutrition·K T ChungY Lin
Jul 25, 2003·Expert Opinion on Pharmacotherapy·Sujit Kumar Bhattacharya, Dipika Sur
Dec 24, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Francis A Waldvogel
Feb 28, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C A TanakaB P Dias Filho
Feb 13, 2009·Nature·M LeaverJ Errington
Jan 1, 2007·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Rajesh DaburG S Lavekar
Oct 22, 2011·International Journal of Molecular Sciences·Seong-Cheol ParkKyung-Soo Hahm
Apr 24, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H C Schønheyder, M Paul
Jan 29, 2014·TheScientificWorldJournal·Shashank Kumar, Abhay K Pandey
Feb 22, 2014·Journal of Ethnobiology and Ethnomedicine·Wilson KipkoreGabriel Kigen

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

MS excel
Minitab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Alternative Medicine Review : a Journal of Clinical Therapeutic
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Yuan RuanYao-Sheng Wu
© 2021 Meta ULC. All rights reserved