Abstract
Menorrhagia is a common health problem in women, particularly those with bleeding disorders. Little is known about the course of menorrhagia or other bleeding symptoms in women with the most common congenital bleeding disorder, von Willebrand disease (vWD). The aim of this study was to estimate the prevalence of vWD in women with diagnosed menorrhagia. In this cross-sectional study, a total of 460 consecutive patients, presenting menorrhagia, were analyzed. The initial screening and confirmation tests for the diagnosis of vWD included determination of prothrombin time (PT), partial thromboplastin time (PTT), bleeding time (BT), fibrinogen, factor VIII, vWF antigen, and vWF activity. A questionnaire was filled for every patient. The data were then analyzed using the SPSS software. Mean age of our patients was 32.5 ± 10.6 years. The level of von Willebrand factor in 22.5% and von Willebrand activity in 19.6% of patients was abnormal. The prevalence of vWD among patients with menorrhagia was 24%. The high prevalence of vWD among our patients was the same as other previous reports, suggesting low awareness about this disease and under diagnosis of mild cases.
References
Jun 1, 1995·Obstetrics and Gynecology·C A JanssenA P Heintz
Mar 29, 2001·Obstetrics and Gynecology·A DilleyB Evatt
May 9, 2001·American Journal of Hematology·C H MillerB L Evatt
Jul 7, 2001·BMJ : British Medical Journal·P WarnerG Murray
Sep 26, 2001·Journal of Women's Health & Gender-based Medicine·D Goodman-Gruen, K Hollenbach
Nov 1, 2001·Best Practice & Research. Clinical Haematology·P A Kouides
Feb 28, 2002·Journal of Women's Health & Gender-based Medicine·Anne DilleyBruce Evatt
Mar 27, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Y L WooO P Smith
Nov 2, 2002·Blood·J Evan Sadler
Mar 5, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·R SaxenaM Bhargava
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·C S PhilippP Saidi
May 29, 2004·American Journal of Obstetrics and Gynecology·Pamela E WarnerGordon D Murray
Jun 17, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Meena ShankarRezan A Kadir
Aug 5, 2004·Obstetrics and Gynecology·Andra JamesEvan R Myers
Oct 2, 2004·Obstetrics and Gynecology·Andrea S Lukes, Peter A Kouides
Dec 31, 2004·Obstetrics and Gynecology·Claire S PhilippParvin Saidi
Jun 28, 2005·American Journal of Hematology·Jody L Kujovich
Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·A H James
Nov 7, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·A B FedericiC A Lee
May 24, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·Y-C ChenJ-Y Liu
Apr 27, 2010·American Journal of Obstetrics and Gynecology·Luis D PachecoAnthony C Sciscione
Feb 25, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Malcolm G MunroUNKNOWN FIGO Working Group on Menstrual Disorders
Aug 24, 2011·Journal of Pediatric and Adolescent Gynecology·Hillary Brooke Boswell
Nov 22, 2011·Seminars in Thrombosis and Hemostasis·Nader Cohan, Mehran Karimi
Dec 14, 2011·Thrombosis and Haemostasis·H Marieke KnolKarina Meijer
Jan 10, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S SandersP James
May 16, 2012·The American Journal of Nursing·Josie A Weiss