Screening Small Metabolites from Cells as Multifunctional Coatings Simultaneously Improves Nanomaterial Biocompatibility and Functionality

Advanced Science
Anqi SunXiangang Hu

Abstract

Currently, nanomaterials face a dilemma due to their advantageous properties and potential risks to human health. Here, a strategy to improve both nanomaterial biocompatibility and functionality is established by screening small metabolites from cells as nanomaterial coatings. A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t-tests and fold change analysis), partial least squares-discriminant analysis (PLS-DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l-aspartic acid, l-malic acid, myoinositol, d-sorbitol, citric acid, and l-cysteine). The further analysis of cell viability, oxidative stress, and cell apoptosis reveals that d-sorbitol markedly reduces nAg cytotoxicity. Subsequently, small molecule loading, surface oxidation, and ionic release experiments support d-sorbitol as the optimal coating for nAg. Importantly, d-sorbitol loading improves the duration of the antibacterial activity of nAg against Escherichia coli and Staphylococcus aureus. The biocidal persistence of nAg-sorbitol is extended beyond 9 h, and the biocidal effects at 12 h are significantly higher than those of naked nAg. This work proposes a new strategy to improve the biocompatibili...Continue Reading

References

Sep 13, 2008·Current Biology : CB·Cathy Savage-Dunn
Mar 16, 2011·Chemical Reviews·Morteza MahmoudiSophie Laurent
Apr 26, 2011·Environmental Science & Technology·Wen ZhangYongsheng Chen
Dec 7, 2011·Environmental Science & Technology·Rui MaGregory V Lowry
Jul 7, 2012·Nano Letters·Zong-ming XiuPedro J J Alvarez
Mar 16, 2013·Chemical Reviews·Sonja EckhardtKatharina M Fromm
Jun 7, 2013·Advanced Materials·Yi ZhangXingyu Jiang
Mar 22, 2014·Chemical Society Reviews·Yi ZhangBing Yan
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kelsey L Poulson-EllestadBrook L Nunn
Jun 9, 2014·Nature Materials·Gary B BraunErkki Ruoslahti
Dec 24, 2014·Chemical Research in Toxicology·Yi ZhangBing Yan
Aug 28, 2015·Environmental Pollution·Laura Sigg, Ursula Lindauer
Jun 7, 2016·Journal of the American Chemical Society·Paweł PomastowskiBogusław Buszewski
Jul 28, 2016·Nature Communications·Regino Mercado-LuboBeth A McCormick
Aug 6, 2016·ACS Nano·Kaiyuan ZhengJianping Xie
Sep 21, 2016·Trends in Cell Biology·Georgia K Atkin-Smith, Ivan K H Poon
Oct 16, 2016·Environmental Science & Technology·Wei ZhouJohn J Lenhart
Oct 28, 2016·Journal of the American Chemical Society·Ling HuangGang Han
Dec 13, 2016·Journal of the American Chemical Society·Stephen M OjaBo Zhang
Dec 21, 2016·Environmental Science & Technology·Yinqing ZhangLingyan Zhu
Mar 21, 2017·Environment International·Xiangang HuQixing Zhou
Mar 23, 2017·ACS Applied Materials & Interfaces·Anqi SunXiangang Hu

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Methods Mentioned

BETA
chemical modifications
electron microscopy

Software Mentioned

CasaXPS
MetaboAnalyst
PLS
SAM
DA
SPSS Statistics
FlowJo

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