Screening Tool for Early Postnatal Prediction of Retinopathy of Prematurity in Preterm Newborns (STEP-ROP)

Neonatology
Caroline A RicardOlaf Dammann

Abstract

Retinopathy of prematurity (ROP) is a disorder of the preterm newborn characterized by neurovascular disruption in the immature retina that may cause visual impairment and blindness. To develop a clinical screening tool for early postnatal prediction of ROP in preterm newborns based on risk information available within the first 48 h of postnatal life. Using data submitted to the Vermont Oxford Network (VON) between 1995 and 2015, we created logistic regression models based on infants born <28 completed weeks gestational age. We developed a model with 60% of the data and identified birth weight, gestational age, respiratory distress syndrome, non-Hispanic ethnicity, and multiple gestation as predictors of ROP. We tested the model in the remaining 40%, performed tenfold cross-validation, and tested the score in ELGAN study data. Of the 1,052 newborns in the VON database, 627 recorded an ROP status. Forty percent had no ROP, 40% had mild ROP (stages 1 and 2), and 20% had severe ROP (stages 3-5). We created a weighted score to predict any ROP based on the multivariable regression model. A cutoff score of 5 had the best sensitivity (95%, 95% CI 93-97), while maintaining a strong positive predictive value (63%, 95% CI 57-68). When a...Continue Reading

References

Feb 1, 1994·Australian and New Zealand Journal of Ophthalmology·D A ToddE John
Mar 18, 2000·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·V Seiberth, O Linderkamp
Dec 22, 2000·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·D K WallaceJ G Hall
Aug 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·C M WheatleyM M Sale
Dec 5, 2002·Journal of Clinical Epidemiology·Karel G M MoonsEwout W Steyerberg
Jul 9, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Sybil BarrMartin Keszler
Oct 8, 2005·Biology of the Neonate·Ola Didrik Saugstad
Mar 3, 2007·Angiogenesis·Jing Chen, Lois E H Smith
Sep 22, 2009·Early Human Development·T M O'SheaUNKNOWN ELGAN study Investigators
Dec 24, 2010·Clinical Ophthalmology·R V Paul ChanMargaret M Deangelis
Sep 10, 2011·Seminars in Fetal & Neonatal Medicine·Jennifer Lee, Olaf Dammann
Jan 24, 2012·Clinical Ophthalmology·Mário Martins Dos Santos MottaClaudia Amaral Fiorot
Jan 2, 2013·Pediatrics·Walter M FiersonUNKNOWN American Association of Certified Orthoptists
Jun 21, 2013·Lancet·Ann HellströmOlaf Dammann
Jun 21, 2016·Acta Ophthalmologica·Stefano PiermarocchiPaola Lago

❮ Previous
Next ❯

Citations

Apr 7, 2020·Journal of Neonatal-perinatal Medicine·Saif Aldeen AlRyalatAllaa Roto
Apr 22, 2018·Survey of Ophthalmology·Sang Jin KimMichael F Chiang
May 29, 2021·BMC Ophthalmology·Sizhe ChenSongfu Feng
Jul 15, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tahereh BahmaniSalman Daliri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.