PMID: 9183055Mar 1, 1997Paper

Screening toxic effects of volatile organic compounds using Drosophila melanogaster

Journal of Applied Toxicology : JAT
R Wasserkort, T Koller

Abstract

The suitability of Drosophila melanogaster for biological screening of the toxic effects of volatile organic compounds was investigated. Adult flies were exposed to vapours of some organic solvents and gasoline under saturating conditions in the sublethal range. In some cases the dose-response relationship was studied. As a measure of the overall metabolism, CO2 production was recorded before and after exposure, including the recovery period, and the body activity was scored and classified as "normal behaviour", hyperactivity or excitement or narcosis. Significant differences were observed for the different solvents and volatile mixtures (vapours of acetone, benzene, methanol, toluene, xylene, diethylether, leaded and unleaded gasoline and diesel fuel). The length of the narcosis induced by the volatile organic compounds correlated well with their octanol-water coefficients. After exposure to benzene, toluene and gasoline a marked increase in the CO2 production during narcosis was observed. Methanol exposure led to a long-lasting increase in CO2 production, but did not cause narcosis. There were also differences in the behaviour (body activities) in the recovery phase between the solvents tested. Thus, the results from these ex...Continue Reading

Citations

Dec 3, 2014·Neurotoxicology and Teratology·K R Tatum-GibbsP J Bushnell
Aug 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maqusood AhamedM K J Siddiqui
Nov 10, 2012·Environmental Toxicology·Arati A InamdarJoan W Bennett
Jul 21, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Arati A InamdarJoan Wennstrom Bennett
Sep 20, 2018·Environmental Science and Pollution Research International·Samuel Lima de SantanaClaudia Rohde
Sep 25, 2015·Toxins·Joan W Bennett, Arati A Inamdar
May 3, 2014·Current Protocols in Toxicology·Matthew D RandDaria Vorojeikina

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