Scrib, a tumor suppressor gene involved in cell polarity

Médecine sciences : M/S
Naël Osmani, Sandrine Etienne-Manneville

Abstract

Polarity is a fundamental feature of all organisms both during development and in the adult. This reflects the key role of cell polarity during basic fundamental processes such as cell division, cell differentiation and cell migration. The control of cell polarity relies on functionally conserved proteins. Among these, Scribble, initially identified as a tumor suppressor gene in Drosophila, has been first involved in epithelial polarity. More recently Scribble function has been implicated in neuronal polarity and polarized cell migration. Scribble joins the growing family of tumor suppressors that play a key and conserved function in cell polarity. Scribble illustrates the more and more obvious link between regulation of cell polarity, cell transformation and tumor formation.

References

Dec 5, 1998·American Journal of Human Genetics·H MehenniS E Antonarakis
Mar 18, 1999·The American Journal of Pathology·E AvizienyteL A Aaltonen
Aug 10, 1999·Genes, Chromosomes & Cancer·S RothL A Aaltonen
Aug 12, 1999·Biochemical and Biophysical Research Communications·J NezuM Shimane
Jun 14, 2002·Cell·Miho Iijima, Peter Devreotes
Jun 22, 2002·Gut·R SalovaaraL A Aaltonen
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Juliane P CavistonErfei Bi
Jan 3, 2003·Nature Cell Biology·David BilderNorbert Perrimon
Mar 1, 2003·Nature·Sandrine Etienne-Manneville, Alan Hall
Jun 28, 2003·FEBS Letters·Jérôme BoudeauDario R Alessi
Oct 28, 2003·EMBO Reports·Renaud LegouisMichel Labouesse
Dec 4, 2003·Médecine sciences : M/S·Sandrine Etienne-Manneville
Dec 19, 2003·Oncogene·Lukas E DowPatrick O Humbert
Feb 11, 2004·Médecine sciences : M/S·David GodreauStéphane Hatem
Jun 9, 2004·Current Biology : CB·Stéphane AudebertJean-Paul Borg
Dec 22, 2004·The Journal of Cell Biology·Jennifer ZeitlerDavid Bilder
Sep 15, 2005·The Journal of Cell Biology·Sandrine Etienne-MannevilleAlan Hall
Jun 23, 2006·Journal of Cellular Biochemistry·Laura M KallayLelita T Braiterman
Nov 4, 2006·Current Biology : CB·Naël OsmaniSandrine Etienne-Manneville
Aug 22, 2008·Human Molecular Genetics·Sébastien NolaMarie-Josée Santoni
Jun 3, 2009·The Journal of Cell Biology·Isabelle DupinSandrine Etienne-Manneville
Mar 23, 2012·Cold Spring Harbor Perspectives in Biology·Paul Polakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Developmental Neuroscience
Valeri Vasioukhin
BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Patrick O HumbertHelena E Richardson
© 2021 Meta ULC. All rights reserved