Scurvy. A rare differential diagnosis of rheumatic diseases

Zeitschrift für Rheumatologie
K HofheinzB Manger

Abstract

In December 2014 a patient presented to our clinic with the clinical symptoms of vasculitis. However, treatment with glucocorticoids did not lead to any improvement; therefore, the differential diagnostics were extended to other indications and ultimately led to the diagnosis of scurvy. This article describes the clinical picture of scurvy and its relationship to rheumatic diseases based on a clinical case and additional information from the literature. Differences and similarities with important rheumatological disease symptoms are presented. Scurvy is a rare hypovitaminosis disease which can be manifested in different forms. In addition to vasculitis the symptoms can also resemble arthritis and hemarthrosis is a typical finding. These symptoms can be accompanied by unspecific manifestations, such as muscle pain and due to impaired collagen synthesis characteristic features, such as corkscrew hair can be observed. The causal therapy of scurvy is substitution of ascorbic acid. Scurvy is a rare differential diagnosis in the context of rheumatic diseases. The indications for scurvy can be a lack of response to immunosuppressive and immunomodulatory drugs as well as individual symptoms, such as corkscrew hair.

References

May 14, 1970·The New England Journal of Medicine·J HoodR E Hodges
Mar 1, 1996·Arthritis and Rheumatism·C L MehtaA J Bridges
Dec 1, 1995·Metabolism: Clinical and Experimental·C J Rebouche
Jan 1, 1996·Sub-cellular Biochemistry·I P RonchettiG Bergamini
Nov 26, 1999·Journal of the American Academy of Dermatology·J V Hirschmann, G J Raugi
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·A C ChanD Chiu
Sep 5, 2001·Pediatrics·M WeinsteinS Zlotkin
Feb 8, 2007·The American Journal of Dermatopathology·J Andrew Carlson, Ko-Ron Chen
Mar 14, 2007·The British Journal of Nutrition·Serena GuarnieriMarisa Porrini
Jun 11, 2009·British Journal of Pharmacology·J MandlG Bánhegyi
Apr 9, 2010·International Journal of Rheumatic Diseases·Herman LauFredrick Joshua
Dec 28, 2010·Seminars in Arthritis and Rheumatism·Marty T Mertens, Elie Gertner
Jul 29, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Margherita EstienneTiziana Granata
Jul 17, 2012·Chest·Markku Kupari, Janne Rapola
Sep 15, 2012·International Journal of Experimental Pathology·Jin-Kyu ParkKyu-Shik Jeong
Dec 3, 2013·Osteoarthritis and Cartilage·R K ChagantiUNKNOWN Multicenter Osteoarthritis Study Group (MOST)
Jun 8, 2014·Biochimica Et Biophysica Acta·Gábor BánhegyiAndrás Szarka
Jul 23, 2014·Free Radical Biology & Medicine·Darius J R Lane, Des R Richardson
Aug 20, 2014·Nature Reviews. Rheumatology·Bernhard Manger, Georg Schett
Sep 4, 2014·Critical Care : the Official Journal of the Critical Care Forum·Heleen M Oudemans-van StraatenMonique C de Waard
Nov 12, 2014·Journal of the American College of Nutrition·Divya SanghiRajeshwar Nath Srivastava
Apr 10, 2015·Current Rheumatology Reports·Claudia FerrariCarlo Salvarani

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Rheumatology Reports
Claudia FerrariCarlo Salvarani
The Journal of Rheumatology
Ian Haslock
Postgraduate Medical Journal
Juan Nicolas LessingNicholas Maxwell Mark
© 2022 Meta ULC. All rights reserved