Scutellaria barbata D. Don induces c-fos gene expression in human uterine leiomyomal cells by activating beta2-adrenergic receptors

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
T-K LeeC-H Kim

Abstract

Scutellaria barbata D. Don (Lamiaceae; SB) inhibited the growth of uterine leiomyomal (LM) cells with unknown actions. The expression patterns of beta-adrenergic receptors (beta-ARs) in human uterine LM cells and functional coupling to gene expression have also been investigated. Northern blot analysis showed that beta-AR subtypes are expressed at different levels in the uterine LM cells and myometrial smooth muscle cells (SMCs). beta1-AR expression was to be found approximately at the same level in the two cell types. beta2-ARs were expressed at higher levels in uterine LM cells than that in myometrial SMCs. beta3-AR expression was not found in both the cells. c-fos gene expression was induced by SB in uterine LM cells via increases in adenosine-3',5', cyclic monophosphate (cAMP), which in turn activated the cAMP/protein kinase A (PKA) pathway. The PKA inhibitor, H89, inhibited c-fos gene expression induced by SB. It seems that the mechanism of proto-oncogenes c-fos different leiomyoma from other myometrial cancer. Further studies are necessary to elucidate whether c-fos induction by SB in uterine LM cells influences a regression of leiomyoma or induces other differentiation.

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Citations

May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C-H KimI-S Lee
Dec 26, 2008·World Journal of Gastroenterology : WJG·Zhi-Jun DaiLing-Qin Song
May 31, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Jun DaiXi-Jing Wang
Nov 28, 2006·Phytotherapy Research : PTR·Seok-Jong SuhCheorl-Ho Kim
Mar 8, 2019·Cell Transplantation·Veronika AleksandrovychKrzysztof Gil
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Benjiao GongHuishan Zhao

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