Abstract
Hypoxia, a hallmark of many solid tumors, is associated with angiogenesis and tumor progression. Hypoxia-inducible factor-1 (HIF-1) plays a significant role in tumor angiogenesis. In this study, the authors constructed a selective platform to screen the traditional Chinese medicine as anti-angiogenic agent. The authors examined the molecular mechanism by which Scutellaria barbata regulates HIF-1-dependent expression of vascular endothelial growth factor (VEGF), which is an important angiogenic factor. Hypoxia promotes angiogenesis by increasing VEGF expression and secretion. Herein, the expression of VEGF was decreased by treatment with S. barbata in tumor cells. Meanwhile, S. barbata reduced the migration and proliferation of endothelial cells under hypoxic condition. S. barbata inhibited the expression of HIF-1α, as well as phosphorylated their upstream signal mediators AKT. S. barbata significantly inhibited the tumor growth in vivo and immunohistochemical studies in the tumors revealed decreased intratumoral microvessel density. These results suggest that the traditional Chinese medicine therapy using S. barbata, which exerts anti-angiogenic activities, represents a promising strategy for the treatment of tumors.
References
Jan 4, 1996·Nature·T G GraeberA J Giaccia
Dec 20, 1996·The Journal of Biological Chemistry·G L SemenzaA Giallongo
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Dec 15, 2000·Oncogene·M KriegK H Plate
Jul 12, 2003·The Journal of Biological Chemistry·Young-Gun YooMi-Ock Lee
Aug 13, 2003·The Journal of Urology·Lisa J FrederiksenCharles H Graham
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bogdan Z OlenyukPeter B Dervan
Dec 23, 2006·Human Gene Therapy·Che-Hsin LeeAi-Li Shiau
Aug 4, 2007·Phytotherapy Research : PTR·Jianqing YuGuolin Zou
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·Che-Hsin LeeAi-Li Shiau
Dec 26, 2008·World Journal of Gastroenterology : WJG·Zhi-Jun DaiLing-Qin Song
Feb 9, 2010·Acta Pharmacologica Sinica·Ya-yin ChenJaung-geng Lin
Apr 10, 2010·Cancer Letters·Hyun Seung BanHiroyuki Nakamura
May 1, 2010·BMC Cancer·Jean-San ChiaWon-Bo Wang
Jun 1, 2010·BMC Cancer·Ai-Li ShiauChe-Hsin Lee
Citations
May 25, 2013·Brain Research Bulletin·Peng ZhangJianxun Liu
Jul 3, 2013·BMC Complementary and Alternative Medicine·Zhi-Jun DaiWen-Ying Wu
Sep 11, 2014·Journal of Cancer Research and Therapeutics·Xiaochun Qiu, Jack Jia
Jun 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Kun YangZhao-Xia Xu
Dec 31, 2014·International Journal of Molecular Sciences·Wei-Kuang WangChe-Hsin Lee
Feb 16, 2016·Journal of Ethnopharmacology·Geyang Tao, Marcy J Balunas
Dec 2, 2015·Oncology Letters·Lin YeWen G Jiang
Feb 24, 2016·International Journal of Molecular Sciences·Yu-Tzu TsaoChe-Hsin Lee
Jul 22, 2014·Environmental Toxicology·Wei-Kuang WangChe-Hsin Lee
Jun 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tao GongShen-Lin Liu
Feb 20, 2015·Medical Oncology·Xiaoli LiZhubo Li
Jan 16, 2015·Gene Therapy·C-S LuA-L Shiau
May 29, 2018·Integrative Cancer Therapies·Cheng ZhangYibin Feng
Jun 6, 2018·Human Gene Therapy·Wei-Kuang WangChe-Hsin Lee
Jan 24, 2014·Gene Therapy·C-H LeeW-K Wang
Dec 28, 2019·Cancers·Man-Chin ChenChe-Hsin Lee
Apr 15, 2017·Oncotarget·Li-Fang ShenMin-Li Zhou
Oct 31, 2015·Oncotarget·Yu-Diao Kuan, Che-Hsin Lee
Oct 23, 2016·Oncotarget·Dom-Gene TuChe-Hsin Lee
Apr 25, 2019·International Journal of Molecular Medicine·Qing HuXingen Zhu
Feb 3, 2018·International Journal of Molecular Medicine·Shan-Tong JiangPing-Ping Li
Jan 8, 2017·Molecular and Cellular Biochemistry·Fang ZhouJianjun Wang
Jul 13, 2019·Frontiers in Pharmacology·Ming HongYibin Feng
Oct 23, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Wei LiuMing Q Wei
Jun 3, 2021·Viruses·Sheng-Teng HuangMien-Chie Hung
Jun 10, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wenjun Li, Hongxia Xiao