Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor

Environmental Toxicology
Ai-Li ShiauChe-Hsin Lee

Abstract

Hypoxia, a hallmark of many solid tumors, is associated with angiogenesis and tumor progression. Hypoxia-inducible factor-1 (HIF-1) plays a significant role in tumor angiogenesis. In this study, the authors constructed a selective platform to screen the traditional Chinese medicine as anti-angiogenic agent. The authors examined the molecular mechanism by which Scutellaria barbata regulates HIF-1-dependent expression of vascular endothelial growth factor (VEGF), which is an important angiogenic factor. Hypoxia promotes angiogenesis by increasing VEGF expression and secretion. Herein, the expression of VEGF was decreased by treatment with S. barbata in tumor cells. Meanwhile, S. barbata reduced the migration and proliferation of endothelial cells under hypoxic condition. S. barbata inhibited the expression of HIF-1α, as well as phosphorylated their upstream signal mediators AKT. S. barbata significantly inhibited the tumor growth in vivo and immunohistochemical studies in the tumors revealed decreased intratumoral microvessel density. These results suggest that the traditional Chinese medicine therapy using S. barbata, which exerts anti-angiogenic activities, represents a promising strategy for the treatment of tumors.

References

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Citations

Jul 3, 2013·BMC Complementary and Alternative Medicine·Zhi-Jun DaiWen-Ying Wu
Sep 11, 2014·Journal of Cancer Research and Therapeutics·Xiaochun Qiu, Jack Jia
Jun 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Kun YangZhao-Xia Xu
Feb 24, 2016·International Journal of Molecular Sciences·Yu-Tzu TsaoChe-Hsin Lee
Jul 22, 2014·Environmental Toxicology·Wei-Kuang WangChe-Hsin Lee
Jun 6, 2018·Human Gene Therapy·Wei-Kuang WangChe-Hsin Lee
Jan 8, 2017·Molecular and Cellular Biochemistry·Fang ZhouJianjun Wang
Oct 23, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Wei LiuMing Q Wei
Jun 10, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wenjun Li, Hongxia Xiao

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