PMID: 9630860Jun 19, 1998Paper

Scytalols A, B, C, and D and other modulators of melanin biosynthesis from Scytalidium sp. 36-93

The Journal of Antibiotics
E ThinesO Sterner

Abstract

From submerged cultures of Scytalidium sp. 36-93, ten metabolites were isolated due to their effects on dihydroxynaphthalene (DHN) or DOPA melanin biosynthesis. Four of the compounds, scytalols A (1a), B (1b), C (2) and D (3), are new secondary metabolites, the structures of which were determined by spectroscopy, while the other compounds are known. Scytalols A (1a) and D (3) are selective inhibitors of DHN melanin biosynthesis and exhibit no antifungal or cytotoxic activities. Nectriapyrone, 6-methoxymellein and 4-chloro-6-methoxymellein stimulated the formation of DOPA melanin in B16-F1 melanoma cells in the absence of melanin-stimulating hormone.

Citations

Dec 18, 2007·FEMS Immunology and Medical Microbiology·Denise O GuimarãesMônica T Pupo
Nov 18, 2018·Chembiochem : a European Journal of Chemical Biology·Takayuki MotoyamaHiroyuki Osada
Feb 24, 2009·Chemistry & Biodiversity·Muftah A M ShushniRolf Jansen
Nov 22, 2020·International Journal of Molecular Sciences·Takayuki Motoyama
Aug 7, 2004·Journal of Clinical Microbiology·R Morris-JonesA J Hamilton
May 13, 2020·Journal of Natural Products·Fei XieHong-Xiang Lou
Aug 25, 2016·Journal of Natural Products·Yan-Hui ZhouHong-Xiang Lou
Jan 27, 2018·Journal of Natural Products·Chayanika PadumadasaA A Leslie Gunatilaka
Aug 12, 2021·Journal of Industrial Microbiology & Biotechnology·Takayuki MotoyamaHiroyuki Osada

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