SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells

Journal of Cardiovascular Translational Research
Andrew B GoldstoneY Joseph Woo

Abstract

Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.

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Citations

Feb 5, 2019·Advanced Healthcare Materials·Amanda N SteeleYiping Joseph Woo
Feb 15, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Heidi NoelsRory R Koenen
May 18, 2020·Journal of Cardiovascular Translational Research·Bijun Chen, Nikolaos G Frangogiannis
Mar 4, 2021·Current Cardiology Reports·Kyla D BrezitskiRavi Karra
Mar 4, 2021·Current Cardiology Reports·Kristy Red-Horse, Soumyashree Das

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