Sea cucumber (Codonopsis pilosula) oligopeptides: immunomodulatory effects based on stimulating Th cells, cytokine secretion and antibody production

Food & Function
Li-Xia HeYong Li

Abstract

This study aimed to investigate the immunomodulating activity of small molecule oligopeptides from sea cucumber (Codonopsis pilosula) (SOP) in mice. Seven assays were performed to determine the immunomodulatory effects, including splenic lymphocyte proliferation and delayed-type hypersensitivity assays (cell-mediated immunity), IgM antibody response of spleen to sheep red blood cells (SRBC) and serum hemolysin level assays (humoral immunity), the carbon clearance assay and the phagocytic capacity of peritoneal cavity phagocytes assay (macrophage phagocytosis), and the NK cell activity assay. Spleen T lymphocyte subpopulations, multiplex sandwich immunoassays of serum cytokine and immunoglobulin levels and enzyme-linked immunosorbent assays for small intestinal secretory immunoglobulin were performed to study the mechanism by which SOP affects the immune system. We found that SOP could improve immune functions in mice, which may be due to the enhancement of the functions of cell-mediated immunity, humoral immunity, macrophage phagocytosis and NK cell activity. From the cellular and molecular assays, we postulated that the immunomodulatory effects are most likely attributed to the stimulation of Th cells, cytokine secretion and a...Continue Reading

References

Jan 1, 1997·Annual Review of Immunology·S L Constant, K Bottomly
Jan 5, 2005·BioFactors·Hans Meisel
Aug 30, 2005·Immunology Letters·Reinhold E Schmidt, J Engelbert Gessner
Dec 27, 2005·Bioscience, Biotechnology, and Biochemistry·Noboru HoriguchiYoshio Suzuki
Jan 18, 2006·Annual Review of Medicine·David A Randolph, C Garrison Fathman
Jan 18, 2006·Immunity·Falk Nimmerjahn, Jeffrey V Ravetch
Feb 13, 2007·Current Opinion in Biotechnology·Rainer Hartmann, Hans Meisel
Jan 16, 2010·Science·Akiko Iwasaki, Ruslan Medzhitov
Jul 20, 2010·Immunological Reviews·Falk Nimmerjahn, Jeffrey V Ravetch
Jan 12, 2011·Annual Review of Immunology·Andrea CeruttiAlejo Chorny
Jul 23, 2013·Frontiers in Immunology·Blaise Corthésy
Mar 20, 2015·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov

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Citations

Mar 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujing QinJinhua Zhao
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianbing ChenYan Cao
Jun 23, 2018·Journal of Agricultural and Food Chemistry·Ying-Cai ZhaoYu-Ming Wang

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