Sea Cucumber Peptides Improved the Mitochondrial Capacity of Mice: A Potential Mechanism to Enhance Gluconeogenesis and Fat Catabolism during Exercise for Improved Antifatigue Property

Oxidative Medicine and Cellular Longevity
Yihao YuGuowei Le

Abstract

Sea cucumber promotes multifaceted health benefits. However, the mechanisms of sea cucumber peptides (Scp) regulating the antifatigue capacity is still unknown. The present study is aimed at further elucidating the effects and mechanisms of Scp on the antifatigue capacity of mice. At first, C57BL/6J mice were assigned into four groups named Con, L-Scp, M-Scp, and H-Scp and received diets containing Scp (0%, 0.15%, 0.3%, and 0.5%, respectively) for continuous 30 days. On the 21th day, a fore grip test was conducted on mice. On the 25th day, a rotating rod test was conducted on mice. On the 30th day, the quantities of glycogen and mitochondrial DNA (mtDNA) were determined in 8 random mice and another 8 mice were forced to swim for 1 hour before slaughter for detecting biochemical indicators. It was observed that the Scp groups significantly prolonged the running time in rotarod, increased forelimb grip strength, improved lactic acid (LD) and urea nitrogen (BUN) levels in the serum, decreased lactic dehydrogenase (LDH) and glutamic oxalacetic transaminase (GOT) activities in the serum, increased blood glucose (BG) and glycogen (GN) levels in the liver and skeletal muscle after swimming, increased the activity of Na+-K+-ATPase and ...Continue Reading

References

May 20, 1998·Sports Medicine·J A HawleyA Jeukendrup
Dec 19, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jorgen F P WojtaszewskiErik A Richter
Jan 15, 2008·Free Radical Biology & Medicine·Michael B Reid
Jun 19, 2008·Diabetes/metabolism Research and Reviews·Frank Q NuttallMary C Gannon
Aug 22, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M SchreursF R van der Leij
Sep 1, 2011·Journal of Ginseng Research·Ji Young ChoiJae Hoon Cheong
Dec 1, 2015·Trends in Cell Biology·D Grahame HardieAnne Brunet
Feb 2, 2016·Current Protocols in Toxicology·Claudia P Gonzalez-HuntJoel N Meyer
Jul 29, 2016·Journal of Nutritional Science and Vitaminology·Jisu KimKiwon Lim
Aug 2, 2016·Oxidative Medicine and Cellular Longevity·Sergio Di MeoVictor Manuel Victor
Mar 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zebin GuoBaodong Zheng
Mar 25, 2017·Journal of the Science of Food and Agriculture·Jing YeMeitian Xiao
Jun 29, 2017·Oxidative Medicine and Cellular Longevity·Yuho KimDavid A Hood
Sep 12, 2017·BioMed Research International·Ping GengJian-Yong Wu
Jan 14, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zilong ZhaoYan Chen
Apr 27, 2018·Endocrine Reviews·Reuben L SmithRiekelt H Houtkooper
May 5, 2018·International Journal of Molecular Sciences·Yuri Khotimchenko
Jan 14, 2020·Nature Communications·Myungjin KimJun Hee Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
MDA

Software Mentioned

Pro Plus
SPSS
Image

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.