PMID: 11916899Mar 28, 2002Paper

Sea level and acute responses to hypoxia: do they predict physiological responses and acute mountain sickness at altitude?

British Journal of Sports Medicine
S GrantA Peacock

Abstract

To compare a range of physiological responses to acute sea level hypoxia at simulated altitudes with the same physiological responses and acute mountain sickness (AMS) scores measured at altitude (similar to the simulated altitudes) during a 17 day trek in the Himalayas. Twenty men and women aged 18-54 years took part in the study. End tidal CO(2) tension (PETCO(2)) and saturated oxygen (SaO(2)) were measured using a capnograph. Observations made at sea level and some simulated altitudes were compared with those in the Himalayas. Pairwise correlations were used to examine the correlation between variables and regression, with 95% prediction intervals providing information on how well one variable could be predicted from another for a given subject. There was only a significant correlation for a few comparisons. The 95% prediction intervals for individual SaO(2) values at a range of simulated altitudes were fairly wide going from +/- 4% to +/- 5%. All of the correlations between laboratory and Himalayan PETCO(2) values were not statistically significant. There was a significant correlation for the relation between SaO(2)and PETCO(2) at sea level for the laboratory data (r=-0.51; p=0.05). For the Himalayan data, there were signif...Continue Reading

References

Jun 1, 1970·The Journal of Clinical Investigation·J V WeilR F Grover
Jul 1, 1997·The European Respiratory Journal·A J Peacock, P L Jones

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Citations

Dec 7, 2007·Sleep & Breathing = Schlaf & Atmung·Martin BurtscherMartin Faulhaber
Jan 8, 2014·Travel Medicine and Infectious Disease·Ken Zafren
Jun 27, 2014·Cell Biochemistry and Biophysics·Guoning GuoMinghua Liu
Jul 16, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xuewen RenPing Ye
Jun 3, 2015·Sleep & Breathing = Schlaf & Atmung·Veronika LeichtfriedWolfgang Schobersberger
Apr 28, 2021·Physiological Reports·Alexandra B CobbUNKNOWN Caudwell Xtreme Everest, Xtreme Everest 2009, Xtreme Everest 2 investigators

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