Sea Lions Develop Human-like Vernix Caseosa Delivering Branched Fats and Squalene to the GI Tract

Scientific Reports
Donghao WangJ Thomas Brenna

Abstract

Vernix caseosa, the white waxy coating found on newborn human skin, is thought to be a uniquely human substance. Its signature characteristic is exceptional richness in saturated branched chain fatty acids (BCFA) and squalene. Vernix particles sloughed from the skin suspended in amniotic fluid are swallowed by the human fetus, depositing BCFA/squalene throughout the gastrointestinal (GI) tract, thereby establishing a unique microbial niche that influences development of nascent microbiota. Here we show that late-term California sea lion (Zalophus californianus) fetuses have true vernix caseosa, delivering BCFA and squalene to the fetal GI tract thereby recapitulating the human fetal gut microbial niche. These are the first data demonstrating the production of true vernix caseosa in a species other than Homo sapiens. Its presence in a marine mammal supports the hypothesis of an aquatic habituation period in the evolution of modern humans.

References

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D T Downing, M E Stewart
Aug 1, 1968·The Journal of Investigative Dermatology·N NicolaidesG R Rice
Jan 1, 1972·Chemistry and Physics of Lipids·H EggeF Zilliken
Oct 1, 1972·The British Journal of Dermatology·J A CotterillL Bulusu
Feb 1, 1970·The Journal of Investigative Dermatology·P RamasastryJ S Strauss
Feb 1, 1981·The American Journal of Clinical Nutrition·R A Gibson, G M Kneebone
Nov 9, 2000·The Journal of Investigative Dermatology·W L PickensS B Hoath
Apr 15, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Marty O VisscherSteven B Hoath
Dec 22, 2006·Nature·Kenneth C Catania
Mar 6, 2008·FEMS Microbiology Letters·Tetsuyoshi InoueKazuhiro Fukui
Jul 11, 2008·Pediatric Research·Rinat R Ran-ResslerJ Thomas Brenna
Jan 27, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zih-Rou HuangJia-You Fang
May 17, 2014·The British Journal of Nutrition·Rinat Rivka Ran-ResslerJ Thomas Brenna
Oct 13, 2016·World Journal of Microbiology & Biotechnology·Wen XuYang Wang
Jan 16, 2017·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y YanJ T Brenna
May 4, 2017·Integrative Medicine Research·Peter PatlevičPavol Švorc

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Citations

Sep 12, 2019·The Journal of Obstetrics and Gynaecology Research·Koji NishijimaTakayuki Enomoto
Nov 12, 2020·Journal of Agricultural and Food Chemistry·Dong Hao WangJ Thomas Brenna

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