Sealing 3D-printed parts to poly(dimethylsiloxane) for simple fabrication of Microfluidic devices

Analytica Chimica Acta
Cody S CarrellCharles S Henry

Abstract

Microfluidics has revolutionized the fields of bioanalytical chemistry, cellular biology, and molecular biology. Advancements in microfluidic technologies, however, are often limited by labor, time, and resource-intensive fabrication methods, most commonly a form of photolithography. The advent of 3D printing has helped researchers fabricate proof-of-concept microfluidics more rapidly and at lower costs but suffers from poor resolution and tedious post-processing to remove uncured resin from enclosed channels. Additionally, custom resins and printers are often needed to create entirely enclosed channels, which increases cost and complexity of fabrication. In this work we demonstrate the ability to create microfluidic devices by covalently sealing 3D-printed parts with open-faced channels to polydimethylsiloxane (PDMS). Open-faced channels are easier to print than fully enclosed channels and can be printed using an inexpensive and commercially available stereolithography 3D printer and resin. The 3D-printed parts are sealed to PDMS, a common substrate used in traditional microfluidic fabrication, using two different techniques. The first involves coating the part with a commercially available silicone spray before sealing to PDM...Continue Reading

Citations

Jan 17, 2021·Journal of Chromatography. a·Joshua J DavisJames P Grinias
Nov 20, 2020·Bioactive Materials·Peng ZhangYong He
Jun 12, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Megan A CattertonRebecca R Pompano
Sep 5, 2021·Annals of Biomedical Engineering·Carole S L SpakeAlbert S Woo

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