Sealing effect of a polysaccharide nanosheet for murine cecal puncture

Surgery
Toshinori FujieShinji Takeoka

Abstract

Recent developments in nanobiotechnology have led us to develop a method of producing a free-standing polymer nanosheet composed of polysaccharides (ie, polysaccharide nanosheet) with a thickness of tens of nanometers. Owing to its enormous aspect ratio, the polysaccharide nanosheet is semi-absorbent and has a physical adhesive strength 7.5-fold greater than that of conventional films of >1 microm thickness. Herein, we have investigated the therapeutic sealing effect of this polysaccharide nanosheet on murine cecal puncture as a wound dressing material. Murine cecum was punctured and then overlapped with the polysaccharide nanosheet. Thereafter, we evaluated its sealing effect on bacterial peritonitis as well as the protection offered by the polysaccharide nanosheet against bacterial permeability using an in vitro transmembrane assay. The 39-nm-thick polysaccharide nanosheet overlapped tightly the perforated cecum. No adhering agents were required because of the ability of the polysaccharide nanosheet to adhere to the tissue surface by physical adsorption (eg, van der Waals interaction). Sealing the perforated cecum with the polysaccharide nanosheet increased survival rate without postoperative adhesion by comparison with untre...Continue Reading

References

May 9, 2003·The Annals of Thoracic Surgery·Thomas FabianRonald B Ponn
Sep 28, 2004·Nature Materials·Chaoyang JiangVladimir V Tsukruk
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·I-Chien LiaoKam W Leong
Nov 15, 2005·Biomacromolecules·Hyunmin YiGregory F Payne
May 23, 2006·Nature Materials·Richard VendammeToyoki Kunitake
Oct 3, 2006·Journal of Biomedical Materials Research. Part a·Yoshihiko MurakamiHiromi Kurosawa

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Naoki OtaniKatsuji Shima
Nov 29, 2012·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Joe ParksJon Peter Ver Halen
Jan 30, 2013·Plastic and Reconstructive Surgery·Shimpo AokiDaizoh Saitoh
Jul 1, 2013·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Kohsuke HagisawaShinji Takeoka
Jan 30, 2015·Advanced Healthcare Materials·Claire MongeCatherine Picart
May 21, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Daisuke NiwaShinji Takeoka
Jun 21, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hiromi MiyazakiDaizoh Saitoh
May 9, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Keisuke ItoShinji Takeoka
Apr 21, 2016·Journal of Biomaterials Science. Polymer Edition·Nesma El-SayedLabiba El-Khordagui
Jan 10, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shimpo AokiManabu Kinoshita
Sep 1, 2017·Nanomaterials·Sheng ZhangHiromu Hashimoto
Aug 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maria M Pérez-MadrigalCarlos Alemán
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana MoreiraNatália M Alves
Apr 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joana MoreiraNatália M Alves
Oct 1, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Eugenio Redolfi RivaVirgilio Mattoli
Sep 6, 2012·ACS Applied Materials & Interfaces·Liyan ShenJian Ji
Sep 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Toshinori FujieVirgilio Mattoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.