Abstract
The surgical technique used in liver transplantation has undergone constant evolution in an effort to develop a safe, highly standardized procedure. Despite this, the initial step of recipient hepatectomy has not been the focus of clinical research thus far. Due to advanced coagulopathy in liver transplant recipients, this part of the operation still carries the risk of severe hemorrhage. This trial is designed to compare an electrothermal bipolar vessel sealing device (LigaSure™) and an ultrasound dissector (HARMONIC ACE®+7) with standard surgical techniques during the recipients' hepatectomy in liver transplantation. In a single-center, prospective, randomized, controlled, parallel, three-armed, confirmatory, open trial, LigaSure™ and HARMONIC ACE®+7 will be compared with standard surgical techniques that use titanium clips and conventional knot-tying ligations during recipient hepatectomy in liver transplantation. Intraoperative total blood loss is the primary endpoint of the trial. Secondary endpoints include blood loss during hepatectomy, the duration of both the hepatectomy and the entire surgical procedure, and blood transfusion requirements of the procedure. To generate reliable data, intraoperative blood loss will be r...Continue Reading
References
Sep 22, 1979·Lancet·R Y CalneR Williams
Nov 1, 1989·Annals of Surgery·A TzakisT E Starzl
Nov 1, 1996·The British Journal of Surgery·M ReesS Bygrave
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Jul 27, 2004·Annals of Surgery·Daniel DindoPierre-Alain Clavien
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Luc MassicotteAndré Roy
Feb 18, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·H G D HendriksM J H Slooff
Dec 20, 2007·Transplantation Proceedings·R S MangusA J Tector
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·O Abbasoglu, I Sayek
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·T CheangC H L Law
May 6, 2008·Transplantation Proceedings·I F S F BoinL S Leonardi
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·A SaiuraT Yamaguchi
Apr 29, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Arianeb MehrabiJan Schmidt
Jul 30, 2009·Annals of Surgery·Mami IkedaMasatoshi Makuuchi
Apr 27, 2011·Clinical Transplantation·Katrin HoffmannPeter Schemmer
Apr 28, 2012·Surgical Endoscopy·Petra F JanssenJudith A F Huirne
May 24, 2012·Transplantation·Luc MassicotteAndré Roy
Jul 31, 2012·Transplantation Proceedings·A OlmezS Yilmaz
Dec 21, 2012·World Journal of Surgery·Mats SavlidBengt Isaksson
Jan 9, 2013·Annals of Internal Medicine·An-Wen ChanDavid Moher
Mar 13, 2013·Journal of the American College of Surgeons·Abbas RanaRonald W Busuttil
Jun 8, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Nian-Song QianJia-Hong Dong
Jun 19, 2013·Transplantation Proceedings·J C LamattinaR N Barth
Aug 21, 2013·International Journal of Surgery·Atsushi NanashimaTakeshi Nagayasu
Sep 28, 2014·Journal of the American College of Surgeons·Philipp HoubenPeter Schemmer
Oct 13, 2014·American Journal of Surgery·John WehryRobert C G Martin
Jul 1, 2016·World Journal of Transplantation·Stuart ClelandStuart A McCluskey