PMID: 44749Dec 1, 1979

Search for antiglucocorticoid activity in rat liver in vivo

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
M K AgarwalG Lazar


Estradiol and testosterone both lowered endogenous liver glycogen and at 20-fold higher doses impaired triamcinolone acetonide mediated glyconeogenesis in adult adrenalectomized male rats. Neither steroid influenced liver tyrosine transaminase although tryptophan pyrrolase activity was depressed by testosterone. Progesterone increased liver tryptophan pyrrolase but did not influence other parameters. Cortexolone did not alter either of these processes whereas cortisol induced both enzymes and, at much higher dose levels, gluconeogenesis. Binding of 3H-triamcinolone acetonide to its cytoplasmic receptor in vitro was left unaffected in presence of 20-fold greater concentration of either sex steroid but almost totally abolished by cold, homologous molecules. Similar results were obtained by 3H-cortisol except that estradiol partially competed for 3H-cortisol binding sites even at 20-fold greater concentrations of cold estradiol. Separation on DEAE-cellulose-52 and Ultrogel 44 columns revealed binding of all steroids to macromolecules of comparable physicochemical properties although the ratios of binding to the various subpopulations of the receptor were a function of the steroid in question. These results are discussed in terms o...Continue Reading


Jun 15, 1987·FEBS Letters·M K AgarwalG Lazer
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Feb 27, 1976·Science·A J EisenfeldL Krakoff
Jan 1, 1976·Annual Review of Physiology·J Gorski, F Gannon
Jan 1, 1976·Annual Review of Biochemistry·K R Yamamoto, B M Alberts
Oct 1, 1977·Experimental and Molecular Pathology·H Glaumann, J A Gustafsson
Jan 1, 1977·Psychoneuroendocrinology·B S McEwenI Lieberburg
Dec 6, 1976·Biochemical and Biophysical Research Communications·M K Agarwal

Related Concepts

Progesterone, (9 beta,10 alpha)-Isomer
Estradiol, (16 alpha,17 beta)-Isomer
Tyrosine Aminotransferase
Liver Glycogen
Glucocorticoid Effect
Tryptophan Oxygenase
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer

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