Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Yushan Li, Yasushi Ohizumi

Abstract

20 medicinal plants of Paraguay and 3 medicinal plants of Thailand were examined on nerve growth factor (NGF)-potentiating activities in PC12D cells. The trail results demonstrated that the methanol extracts of four plants, Verbena littoralis, Scoparia dulcis, Artemisia absinthium and Garcinia xanthochymus, markedly enhanced the neurite outgrowth induced by NGF from PC12D cells. Furthermore, utilizing the bioactivity-guided separation we successfully isolated 32, 4 and 5 constituents from V. littoralis, S. dulcis and G. xanthochymus, respectively, including nine iridoid and iridoid glucosides (1-9), two dihydrochalcone dimers (10 and 11), two flavonoids and three flavonoid glycosides (12-16), two sterols (17 and 18), ten triterpenoids (19-28), five xanthones (29-33), one naphthoquinone (34), one benzenepropanamide (35), four phenylethanoid glycosides (36-39) and two other compounds (40 and 41). Among which, 15 compounds (1-4, 10-11, 14-18, 29-31 and 34) were new natural products. The results of pharmacological trails verified that littoralisone (1), gelsemiol (5), 7a-hydroxysemperoside aglucone (6), verbenachalcone (10), littorachalcone (11), stigmast-5-ene 3beta,7alpha,22alpha-triol (18), ursolic acid (19), 3beta-hydroxyurs-11...Continue Reading

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Oct 17, 2003·Phytochemistry·Wisinee ChanmahasathienYasushi Ohizumi
Nov 6, 2003·Chemical & Pharmaceutical Bulletin·Wisinee ChanmahasathienYasushi Ohizumi
Apr 24, 2004·Journal of Natural Products·Yushan LiYasushi Ohizumi

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Citations

Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Isanete Geraldini Costa BieskiDomingos Tabajara de Oliveira Martins
Jan 6, 2006·Chemical & Pharmaceutical Bulletin·Yuanqiang GuoYasushi Ohizumi
May 3, 2007·Chemical & Pharmaceutical Bulletin·Biswanath DindaYoshihiro Harigaya
Apr 19, 2011·Phytochemistry·Bin-Feng ZhangZheng-Tao Wang
Jan 12, 2013·Chemistry : a European Journal·Patrick BurchKarl Gademann
Nov 26, 2015·BMC Complementary and Alternative Medicine·Tavs A AberePauline O Aimator
Oct 18, 2011·Pharmaceutical Biology·Kundan Singh Bora, Anupam Sharma
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Mohammad AliGul Shad Ali
Jul 10, 2020·Journal of Natural Medicines·Yoshiyasu FukuyamaKenichi Harada
Mar 12, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasushi Ohizumi
May 4, 2010·Journal of Ethnopharmacology·Kundan Singh Bora, Anupam Sharma
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nurul Khairina Najwa Che HassanDeny Susanti

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