Search for disease-specific cardiovascular reactivity patterns: developing the methodology

Clinical Science
J E NaschitzI Rosner

Abstract

Aberrations of CVR (cardiovascular reactivity), an expression of autonomic function, lack specificity for a particular disorder. Recently, a CVR pattern particular to chronic fatigue syndrome has been observed. In the present study, we aimed to develop methodologies for assessing disease-specific CVR patterns. As a prototype, a population of 50 consecutive patients with FMF (familial Mediterranean fever) was studied and compared with control populations. A 10 min supine/30 min head-up tilt test with recording of the heart rate and blood pressure or the pulse transit time was performed. Five studies were conducted applying different methods. In each study, statistical analysis identified independent predictors of CVR in FMF. Based on regression coefficients of these predictors, a linear DS (discriminant score) was computed for every subject. Each study established an equation to assess CVR, calculate DS for FMF and determine the sensitivity and specificity of the DS cut-off. In each of the five studies, abnormal CVR was observed in FMF patients. The best accuracy (88% sensitivity and 90.1% specificity for FMF) was obtained by a method based on beat-to-beat heart rate and pulse transit time recordings. Data was processed by fract...Continue Reading

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Citations

Nov 1, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Poorvi KulshreshthaKishore Kumar Deepak
Nov 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Karl K SzpunarDaniel L Schacter

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