Search for Drosophila genes encoding a conserved domain present in the achaete-scute complex and myc proteins

Molecular & General Genetics : MGG
D Beamonte, J Modolell

Abstract

Several genes of the achaete-scute complex (AS-C) of Drosophila melanogaster encode a 60 amino acids long conserved domain which shares a significant homology with a region of the vertebrate myc proteins. Based on these results, the existence of a family of Drosophila genes that would share both this conserved domain and the neurogenic function of the AS-C has been postulated. To test this proposal, we have searched a D. melanogaster genomic library with a probe that encodes the conserved domain. Only under very low stringency hybridization conditions, clones not belonging to the AS-C cross-hybridized with the probe. Those that gave the strongest signals were characterized. Sequencing of the cross-hybridizing regions showed that they had no significant homology with the conserved domain, the sequence similarity extending at the most for 37 nucleotides. Although our results do not conclusively disprove the existence of a family of AS-C-like genes, they indicate that the conservation of the domain would be lower than that found for shared motifs in other families of Drosophila developmental genes.

References

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Citations

Oct 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Garrell, S Campuzano
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong LiRobert H White
Jul 27, 2010·The Journal of Biological Chemistry·François CollardEmile Van Schaftingen
Jun 4, 2002·The Journal of Biological Chemistry·Arie B BrinkmanJohn van der Oost
Apr 2, 2011·The Journal of Biological Chemistry·Julia Lodder-GadaczekMatthias Eckhardt

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