Jun 1, 1976

Search for epizootic-like Venezuelan encephalitis virus at enzootic habitats in Guatemala during 1969-1971

American Journal of Epidemiology
W F SchererJ V Ordonez


Seventy-four strains of Venezuelan encephalitis (VE) virus recovered from sentinel hamsters or mosquitoes at enzootic habitats in Guatemala in the two years following the 1969 epidemic-equine epizootic were examined for ability to produce small plaques in Vero African green monkey kidney cell cultures, like isolates obtained during the epizootic. (a) One strain recovered from a sentinel hamster in late October 1969 at an enzootic habitat near the epicenter of the hemagglutination-inhibition (HI) and equine-virulence properties like epizootic virus; this strain retained its small plaque characteristic after inoculation and recovery from bloods of three horses. (b) None of the other 73 strains produced uniformly small plaques, but 31 formed a few small plaques among large ones. Virions from small plaques of five strains were cloned twice in Vero cell cultures. Four clones produced uniformly small plaques after one more passage in Vero cells; three had hemagglutination-pH properties compatible with epizootic virus or intermediate between epizootic and enzootic virus, but HI tests with these three hemagglutinins or with antibody to the fourth cloned strain showed them to be like Central American enzootic virus. One of three cloned ...Continue Reading

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Mentioned in this Paper

Biological Markers
Hemagglutination Inhibition Tests
Venezuelan equine encephalitis virus
Epithelial Cell of Renal Tubule
Antibodies, Viral
Cercopithecus pygerythrus
Epizootic hemorrhagic disease virus

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