PMID: 9194583May 1, 1997Paper

Search for Kaposi's sarcoma-associated virus DNA in hemangioproliferative disorders and cutaneous malignant lymphoma

Journal of Cutaneous Pathology
U SerflingW Sterry

Abstract

Recently, a Kaposi's sarcoma-associated herpesvirus (KSHV) was discovered. We evaluated by PCR 14 paraffin-embedded specimens with the histological diagnosis of endemic, classic and HIV-associated Kaposi's sarcoma (KS) for the presence of the KSHV DNA sequence. In addition, biopsies of adjacent, histologically unaffected skin, peripheral-blood mononuclear cells (PBMCs) of HIV-infected KS patients, PBMCs of one classic KS patient, and specimens of patients with hemangioproliferative disorders other than KS as well as samples of cutaneous T- and B-cell lymphoma were analyzed for KSHV. In all cases of KS, independent of the KS subtype, KSHV was detected in lesional skin. No KSHV was found in biopsies of the adjacent unaffected skin or PBMCs of HIV-infected KS patients. We found KSHV in the PBMCs of a patient with classical KS. All specimens of cutaneous T- and B-cell lymphomas or lymphomatoid papulosis were negative for KSHV. In addition, the samples with hemangioproliferative disorders other than KS were negative for KSHV. There was one borderline case of KS or acroangiodermatitis that was positive for KSHV. Additional histological sections and clinical evaluation confirmed the diagnosis of classic KS. In summary, the data indica...Continue Reading

References

Nov 1, 1979·Archives of Dermatological Research·W SterryE Bodeux
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
May 4, 1995·The New England Journal of Medicine·B Roizman
Apr 22, 1995·Lancet·H CollandreA Blanchard
May 6, 1995·Lancet·C LebbéF Calvo
Apr 1, 1995·Genitourinary Medicine·P Matondo, S Sivapalan
Jan 5, 1995·Nature·T F Schulz, R A Weiss
Mar 25, 1995·Lancet·Y Q HuangA E Friedman-Kien
Feb 12, 1993·Science·N LisitsynM Wigler
Feb 1, 1996·The Journal of Investigative Dermatology·L KeményF Nagy

❮ Previous
Next ❯

Citations

Jun 11, 2005·Virchows Archiv : an International Journal of Pathology·Dmitry V KazakovMichal Michal
Apr 24, 2004·The American Journal of Surgical Pathology·Dmitry V KazakovMichal Michal
Aug 27, 2005·The American Journal of Dermatopathology·Dmitry V KazakovSaul Suster
Mar 25, 2008·The American Journal of Dermatopathology·Marina VazmitelDmitry V Kazakov
Nov 24, 1998·Journal of Cutaneous Pathology·N LiJ Bhawan
Mar 1, 2005·International Journal of Surgical Pathology·Dmitry V KazakovMichal Michal
Mar 17, 2005·Journal of Cutaneous Pathology·James A RamirezJoan Guitart

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.