Search for the missing lncs: gene regulatory networks in neural crest development and long non-coding RNA biomarkers of Hirschsprung's disease

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J M Rogers

Abstract

Hirschsprung's disease (HSCR), a birth defect characterized by variable aganglionosis of the gut, affects about 1 in 5000 births and is a consequence of abnormal development of neural crest cells, from which enteric ganglia derive. In the companion article in this issue (Shen et al., Neurogasterenterol Motil 28: 266-73), the authors search for long non-coding RNAs (lncRNAs) differentially expressed in bowel tissues of infants with HSCR. Microarray analysis of over 37 000 lncRNAs and 34 000 mRNAs was done. The key result was identification of a set of 5 lncRNAs that is a potential diagnostic biomarker of HSCR. In this minireview, I provide an overview of neural crest development and the gene regulatory networks involved in specification, epithelial-mesenchymal transition, and migration of neural crest cells. Genes involved in later development, proliferation, and differentiation of neural crest cells as they migrate into the gut are also reviewed. Many of these genes are associated with HSCR, including RET, GDNF, GFRα, EDN3, and EDNRB. LncRNAs and their roles in development and disease and their use as biomarkers are discussed. The authors of the companion article previously used a multipronged approach to elucidate the etiology...Continue Reading

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Citations

Apr 13, 2012·PloS One·Konstantin KlemmPeter F Stadler
Jun 30, 2019·International Journal of Molecular Sciences·Ana TorroglosaSalud Borrego
Aug 5, 2020·International Journal of Molecular Sciences·Ana TorroglosaSalud Borrego
Jan 20, 2021·Free Radical Biology & Medicine·Weibing TangYankai Xia
Oct 27, 2020·The Journal of International Medical Research·Yi ZhengWei Zhong

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