Searching for a common mechanism for placenta-mediated pregnancy complications and cardiovascular disease: role of lipoprotein(a)

Fertility and Sterility
Ilaria RomagnuoloCinzia Fatini

Abstract

To investigate lipoprotein(a) [Lp(a)], a well known cardiovascular risk factor, in women with history of placenta-mediated pregnancy complications (PMPC) compared with healthy uneventful-pregnancy women (HW), and the role of LPA gene functional polymorphisms in modulating both Lp(a) levels and PMPC risk. Retrospective observational study. University hospital. A total of 360 women with history of PMPC (154 preeclampsia [PE], 121 stillbirth [SB], and 85 small for gestational age [SGA]) and 270 HW. Not applicable. Lp(a) levels measurement and LPA +93C >T and +121G>A polymorphisms genotyping. In PMPCs we observed higher Lp(a) levels than those found in HW and an association with PMPC risk, also after adjustment for age, familial history of cardiovascular disease, and traditional risk factors. By analyzing Lp(a) concentrations according to each pregnancy complication, we observed significantly higher Lp(a) levels in women with history of SB and PE, conferring 2.5-fold and 2-fold increased risks, respectively; no association with SGA was observed. Lp(a) concentrations progressively and significantly increased as LPA unfavorable allelic burden increased; unfavorable allelic burden influenced SB and PE risk. We evidenced, for the first...Continue Reading

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Citations

Jan 19, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Birsen AydemirRıza Madazlı
Jul 19, 2020·Journal of Clinical Medicine·Wilfried Gyselaers
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May 1, 2021·Human Fertility : Journal of the British Fertility Society·Michela CirilloCinzia Fatini

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