Searching for a mitochondrial root to the decline in muscle function with ageing

Journal of Cachexia, Sarcopenia and Muscle
Marta Gonzalez-FreireLuigi Ferrucci

Abstract

Sarcopenia, the age-related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging and its impact on physiological and economic well-being in older adults. Mitochondria in muscle cells lose their intrinsic efficiency and capacity to produce energy during aging, and it has been hypothesized that such a decline is the main driver of sarcopenia. Oxidative phosphorylation becomes impaired with aging, affecting muscle performance, and contributing to an age-associated decline in mobility. However, it is unclear whether this deterioration is due to a reduced mitochondria population, decreased mitochondrial energetic efficiency, or a reduced capacity to dynamically transport oxygen and nutrients into the mitochondria, and addressing these questions is an active area of research. Further research in humans will require use of new "omics" technologies, progress in neuroimaging techniques that permit energy production assessment, and visualization of molecules critical for energetic metabolism, as well as proxy biomarkers of muscle perfusion.

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Citations

Feb 2, 2019·Journal of Cachexia, Sarcopenia and Muscle·Bumsoo AhnHolly Van Remmen
Jan 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Shuang RongWei Yang
Mar 21, 2020·Aging Cell·Fatemeh AdelniaLuigi Ferrucci
Oct 26, 2018·Circulation Research·Luigi FerrucciEleanor M Simonsick
Mar 29, 2019·Journal of Applied Physiology·Tony ChaoSarah M Greising
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emma L WatsonAlice C Smith
Dec 31, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Cristiana Vitale, Izabella Uchmanowicz
Aug 21, 2019·Cells·Elisa LeporeAntonio Musarò
May 23, 2019·Journal of the American Geriatrics Society·Fatemeh AdelniaLuigi Ferrucci
Dec 31, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jenny L Gonzalez-ArmentaAnthony J A Molina
Nov 21, 2020·Mechanisms of Ageing and Development·Ted Kheng Siang NgDavid Bruce Matchar
Jul 11, 2021·Metabolomics : Official Journal of the Metabolomic Society·Qu TianLuigi Ferrucci

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Methods Mentioned

BETA
biopsy

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