Abstract
The children-of-twins design was used to isolate a potentially causal environmental impact of having an alcoholic parent on offspring alcohol use disorder, by an examination of whether the children of alcoholics were at a higher risk for alcohol use disorders than were the children of nonalcoholic parents, even after correlated familial factors were controlled. Participants were 1,224 male and female twins from 836 twin pairs selected from the Australian Twin Registry, 2,334 of the twins' 18-39-year-old offspring, and 983 spouses of the twins. Lifetime histories of Diagnostic and Statistical Manual of Mental Disorders (4th ed.) alcohol use disorders were obtained by structured, psychiatric, telephone interviews conducted individually with each of the family members. Comparisons of the offspring of twins who were discordant for alcoholism indicated that there was no longer a statistically significant difference between the children of alcoholics and the children of nonalcoholics after genetic and family environmental factors correlated with having an alcoholic parent were controlled. The results of this study suggest that the direct causal effect of being exposed to an alcoholic parent on offspring alcohol use disorder is modest...Continue Reading
Citations
Feb 16, 2010·Behavior Genetics·Laura B KoenigHong Xian
Jun 14, 2012·Behavior Genetics·Quetzal A ClassJenae M Neiderhiser
Nov 9, 2010·Psychological Medicine·A L SinghN G Martin
Sep 29, 2011·Journal of Abnormal Psychology·Jackson A GoodnightBrian M D'Onofrio
Feb 13, 2010·Addiction Biology·Kenneth J SherAndrew C Heath
Oct 7, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Mary WaldronAndrew C Heath
Jul 14, 2009·Clinical Psychology Review·Marya T SchulteSandra A Brown
Dec 19, 2015·Systematic Reviews·Amelia M UsherCandice Dwyer
Feb 14, 2009·Addiction·Serena M KingMatt McGue
Jan 3, 2013·Alcoholism, Clinical and Experimental Research·Jarrod M EllingsonNicholas G Martin
Dec 7, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Judy L SilbergLindon J Eaves
Jun 17, 2011·Alcoholism, Clinical and Experimental Research·Holger J SørensenErik L Mortensen
Apr 22, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·K Paige Harden
Aug 8, 2015·Alcoholism, Clinical and Experimental Research·Matthew R LeeKenneth J Sher
Jun 24, 2015·Addictive Behaviors·Christine McCauley Ohannessian
Oct 15, 2013·Drug and Alcohol Dependence·Mary WaldronAndrew C Heath
Jan 16, 2017·Preventive Medicine·Veronica S C PisingerJanne S Tolstrup
Oct 16, 2018·Substance Use & Misuse·Michael LyversFred Arne Thorberg
Sep 4, 2018·Development and Psychopathology·Jinni SuDanielle M Dick
Dec 18, 2019·Addiction·Charlotte HolstUlrik Becker
Jul 1, 2020·Psychological Medicine·Antti LatvalaPaul Lichtenstein
Dec 27, 2016·Frontiers in Neuroscience·Argelia E Rojas-MayorquínDaniel Ortuño-Sahagún
Jul 2, 2018·Behavior Genetics·Tom A McAdamsFruhling V Rijsdijk
Nov 14, 2020·International Journal of Environmental Research and Public Health·Narongsak NoosornNuansiri Kedsai
Jan 1, 2014·Journal of Child & Adolescent Substance Abuse·Linda R StanleyR Dale Walker
Dec 23, 2021·Child Development·Giacomo BignardiDuncan E Astle