Searching for antigenotoxic properties of marine macroalgae dietary supplementation against endogenous and exogenous challenges

Journal of Toxicology and Environmental Health. Part a
Ana MarquesMário Pacheco

Abstract

The functional characterization of marine macroalgae toward their potential to strength genome protection is still scarce. Hence, the aim of this study was to assess the antigenotoxic potential of Ulva rigida, Fucus vesiculosus, and Gracilaria species in Drosophila melanogaster following dietary exposure and adopting the somatic mutation and recombination test (SMART). All macroalgae displayed a genoprotection activity, namely against an exogenous challenge (streptonigrin). The action against subtler endogenous pressures was also noted indicating that supplementation level is a critical factor. Gracilaria species provided ambivalent indications, since 10% of G. vermiculophylla inhibited the egg laying and/or larvae development, while 10% of G. gracilis promoted spontaneous genotoxicity. The effects of U. rigida were modulated (in intensity) by the growing conditions, demonstrating higher genoprotection against streptonigrin-induced damage when grown in an aquaculture-controlled system, while the effectiveness against spontaneous genotoxicity was more apparent in specimens grown under wild conditions. In contrast, F. vesiculosus did not produce significant differences in its potential under varying growing conditions. Overall, t...Continue Reading

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Citations

Mar 20, 2020·Critical Reviews in Food Science and Nutrition·Maushmi S Kumar, Simran A Sharma

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Datasets Mentioned

BETA
MH682138
MH682140
MH682139

Methods Mentioned

BETA
PCR
genoprotection

Software Mentioned

MAFFT
Basic Local Alignment Search Tool
IQTREE
ALGAplus
SMART
INS

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