Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application.

Clinical and Experimental Nephrology
Kiyoshi MoriKazuwa Nakao

Abstract

In this review, isolation and characterization of several kidney-derived molecules are described, namely carbonic anhydrase XIV, cysteine-rich protein 61, and kidney-liver-specific immunoglobulin-like protein. Features of neutrophil gelatinase-associated lipocalin (LCN2 or human neutrophil lipocalin) as a kidney differentiation inducer and renal injury biomarker and also as an iron-carrier protein are also summarized. Furthermore, the concepts of forest fire theory and the biology of siderophore-binding proteins are discussed.

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