Searching for trial protocols: A comparison of methods

Research Synthesis Methods
Anthea SuttonAndrew Booth

Abstract

Registration and publication of trial protocols has become increasingly important and a requirement in some sources of funding and publication. Increased access to protocols yields many potential benefits, but there are issues regarding identification of published protocols. The aim of this investigation is to compare methods of retrieval for identifying trial protocols in a systematic review. Six stages of searching (checking published trial reports, searching journal Web sites, Internet searching, trial registers, bibliographic databases, and contact with authors) were completed to identify 74 trial protocols. Fifty-seven percent of the trial protocols were identified upon completion of all 6 stages of searching. The most comprehensive method was searching trial registers that identified 51% of the protocols. Contact with authors was most effective at uniquely identifying protocols; 12% were retrieved via this single method. Contact with authors was the only effective method of identifying protocols for trials pre-2005. When attempting to identify trial protocols to include in systematic reviews, some methods are relatively quick to undertake but deliver a low yield. The most effective search strategy for most sources was ret...Continue Reading

References

May 27, 2004·JAMA : the Journal of the American Medical Association·An-Wen ChanDouglas G Altman
Sep 10, 2004·The New England Journal of Medicine·Catherine De AngelisUNKNOWN International Committee of Medical Journal Editors
Sep 29, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·An-Wen ChanDouglas G Altman
Jun 2, 2007·Obstetrics and Gynecology·Lisa N AbaidKenneth F Schulz
Nov 26, 2009·Obstetrics and Gynecology·Iain Chalmers, Paul Glasziou
Mar 26, 2010·Annals of Internal Medicine·Kenneth F SchulzUNKNOWN CONSORT Group
Aug 4, 2010·Annals of Internal Medicine·Florence T BourgeoisKenneth D Mandl
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Kerry DwanPaula R Williamson
Mar 4, 2011·The New England Journal of Medicine·Deborah A ZarinNicholas C Ide
Mar 9, 2011·PloS One·Roderik F Viergever, Davina Ghersi
Oct 13, 2011·Regional Anesthesia and Pain Medicine·Michael J Fredrickson, Brian M Ilfeld
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Taryn Young, Sally Hopewell
Sep 26, 2012·Systematic Reviews·Jennifer M TetzlaffDavid Moher
Nov 21, 2012·PloS One·Fleur T van de WeteringLotty Hooft
Jan 11, 2013·BMJ : British Medical Journal·An-Wen ChanDavid Moher
Jan 12, 2013·Lancet·An-Wen ChanDavid Moher
Apr 25, 2013·BMJ : British Medical Journal·Jeppe Bennekou SchrollPeter C Gøtzsche
Jan 15, 2014·Lancet·Paul GlasziouElizabeth Wager
Apr 2, 2014·Annals of Internal Medicine·Daniel M HartungMark Helfand
Mar 1, 2017·Trials·Claudia PansieriMaurizio Bonati

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Citations

Sep 4, 2018·Research Synthesis Methods·Suzy Paisley, Margaret J Foster
Sep 25, 2018·Research Synthesis Methods·Andrew Booth

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