Searching susceptibility loci for bipolar disorder: a sib pair study on chromosome 12

Neuropsychobiology
Cristina LorenziEnrico Smeraldi

Abstract

Several linkage studies demonstrated that different chromosomal regions are involved in the susceptibility to bipolar disorder. In particular, some genome scans evidenced the role of chromosome 12. For this reason, our group chose this chromosome for a preliminary genome scan on a sample of 137 Italian sib pairs, including at least 1 bipolar subject. The analyses were carried out by means of DNA extracted from whole blood. DNA samples were genotyped by 19 simple tandem repeat markers (microsatellites). Starting from the genetic data, we performed two- and multipoint linkage analyses (both parametric and nonparametric) by means of Easy Linkage plus package (version 5.05). The multipoint linkage analyses pointed out a region suggestive of linkage between the markers D12S310 and D12S364, at locus 12p12. In particular, we reached the best evidence of linkage performing multipoint analyses and assuming a recessive model, under the hypothesis of genetic heterogeneity (heterogeneity LOD score = 2.01 and alpha = 0.77). It is interesting to notice that the region at the marker D12S364 is located inside the gene coding for the glutamatergic receptor GRIN2B. Therefore, our finding not only confirmed the role of genetics in determining lia...Continue Reading

Citations

Aug 12, 2014·PloS One·Stéphane JamainMarion Leboyer
Oct 19, 2011·Pharmacology, Biochemistry, and Behavior·Stephen D GinsbergJohn F Smiley
Aug 25, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chiara Fabbri, Alessandro Serretti

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