Searsia chirindensis reverses the potentiating effect of prenatal stress on the development of febrile seizures and decreased plasma interleukin-1β levels

Neuroscience Research
Lihle QuluMusa V Mabandla

Abstract

It is estimated that more than 80% of patients with epilepsy live in developing countries with 50-60% of them being children. This high prevalence is perpetuated by low socio-economic challenges, poor health care facilities and lack of drug affordability. Searsia chirindensis formerly known as rhus chirindensis and commonly known as 'Red Current' is a popular traditional medicinal plant, which has been used to treat a number of illnesses such as heart complaints and neurological disorders. The aim of this study is to investigate the effects of S. chirindensis on the development of febrile seizure in a prenatally stressed rat. Febrile seizures were induced by administering lipopolysaccharide to 14-day-old rat pups followed by kainic acid. A subset of the rats was treated with Searsia after induction of febrile seizures. Interleukin-1β (IL-1β) levels were measured in plasma. Lipid peroxidation was determined in liver tissue. Our data shows that treatment with Searsia reduced interleukin-1β levels in plasma of the febrile seizure rats and prevented lipid oxidation in the liver. Prenatal stress is dampened by the beneficial effects of Searsia on seizure development in rat pups. These results highlight the potentiating effects of Se...Continue Reading

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Citations

Apr 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hanène Ben MiledOlfa Tebourbi
Dec 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zulfiah Mohamed Moosa, Musa Mabandla
Jun 6, 2017·Journal of Experimental Neuroscience·Nombuso Valencia Pearl MkhizeMusa Vuyisile Mabandla
Nov 23, 2017·Frontiers in Neuroanatomy·Vivienne A Russell
Nov 24, 2020·Neuroscience Insights·Palesa MosiliLihle Qulu

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