PMID: 7397562Sep 15, 1980

Seasonal and activity-dependent variations of piperidine levels in the amphibian brain

Brain Research
T MiyataY Kasé


Piperidine is one of biogenic amines possessing nicotine-like synaptotropic actions on the nervous systems. Since piperidine produces multiplex physiological actions, a role for the amine as a modulator in neuroendocrine as well as neuronal functions has been supposed. In the present study, piperidine levels in the amphobian brains during activity and hibernation were examined by use of a mass fragmentographic technique and it was found that the brain piperidine concentrations significantly increased in the cold season especially during hibernation. The significance of the findings is discussed with respect to the hypnogenic effect of piperidine.


Feb 1, 1978·Journal of Neurochemistry·Y E Chang
Feb 1, 1978·Japanese Journal of Pharmacology·Y OkanoY Kasé
Apr 25, 1975·Brain Research·R R Drucker-Colín, E Giacobini
Mar 8, 1976·Biochemical and Biophysical Research Communications·Y F Chang
Dec 7, 1973·Brain Research·M Stepita-KlaucoE Giacobini
Dec 1, 1974·Biomedical Mass Spectrometry·N Seiler, H H Schneider
Feb 8, 1974·Science·M Stepita-KlaucoR Fairweather
May 31, 1974·Brain Research·H DolezalovaR Fairweather

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Hibernation, Artificial
Seasonal Variation

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