Seasonal changes in enzymes of lipogenesis and triacylglycerol synthesis in the golden-mantled ground squirrel (Spermophilus lateralis)

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
P WangR A Coleman

Abstract

In order to determine whether critical enzyme activities of glycerolipid synthesis change seasonally in the golden-mantled ground squirrel (Spermophilus lateralis), we collected summer and winter samples of liver, brown adipose tissue (BAT), and white adipose tissue (WAT). Compared with fatty acid synthase activity during hibernation, summer activities were 2.5- to 8-fold higher in adipose tissue and liver. Diacylglycerol acyltransferase (DGAT) activity was 2.6-fold higher in WAT during the summer, consistent with increased seasonal triacylglycerol storage, but the activity did not change in liver or BAT, suggesting that in these tissues, triacylglycerol synthesis is equally active in summer and winter. Lack of change in acyl-CoA synthetase in liver and BAT may reflect high synthetic rates for acyl-CoAs that are destined in the summer for glycerolipid synthesis and in the winter for beta-oxidation. Monoacylglycerol acyltransferase (MGAT) activity increased significantly in both liver and WAT during the summer but decreased in BAT. Although the changes were consistent with active year-round triacylglycerol synthesis, the higher summer MGAT activity observed in the squirrel liver and WAT suggest that MGATs function may not be lim...Continue Reading

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Citations

Nov 2, 2004·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Gregory L FlorantPhilipp E Scherer
Nov 15, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Gregory L Florant, Jessica E Healy
Dec 4, 2009·Molecular & Cellular Proteomics : MCP·Chunxuan ShaoJun Yan
Dec 24, 2011·PloS One·Jessica P OtisHannah V Carey
May 30, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·David HautonStuart Egginton
Dec 30, 2014·Biochemistry. Biokhimii︠a︡·D Lang-OuelletteP Morin
Jul 14, 2005·Annual Review of Nutrition·John Dark
Dec 18, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·K S RiganoH T Jansen
Jun 10, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sandra L Martin
Jul 30, 2020·Ecology and Evolution·Enrique González-BernardoVincenzo Penteriani
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin

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