Seasonal changes in isoform composition of giant proteins of thick and thin filaments and titin (connectin) phosphorylation level in striated muscles of bears (Ursidae, Mammalia)

Biochemistry. Biokhimii︠a︡
N N SalmovZ A Podlubnaya

Abstract

Seasonal changes in the isoform composition of thick and thin filament proteins (titin, myosin heavy chains (MyHCs), nebulin), as well as in the phosphorylation level of titin in striated muscles of brown bear (Ursus arctos) and hibernating Himalayan black bear (Ursus thibetanus ussuricus) were studied. We found that the changes that lead to skeletal muscle atrophy in bears during hibernation are not accompanied by a decrease in the content of nebulin and intact titin-1 (T1) isoforms. However, a decrease (2.1-3.4-fold) in the content of T2 fragments of titin was observed in bear skeletal muscles (m. gastrocnemius, m. longissimus dorsi, m. biceps) during hibernation. The content of the stiffer N2B titin isoform was observed to increase relative to the content of its more compliant N2BA isoform in the left ventricles of hibernating bears. At the same time, in spite of the absence of decrease in the total content of T1 in the myocardium of hibernating brown bear, the content of T2 fragments decreased ~1.6-fold. The level of titin phosphorylation only slightly increased in the cardiac muscle of hibernating brown bear. In the skeletal muscles of brown bear, the level of titin phosphorylation did not vary between seasons. However, ch...Continue Reading

References

Apr 1, 1988·Archives of Biochemistry and Biophysics·L L Somerville, K Wang
Sep 11, 1986·Nature·R HorowitsR J Podolsky
Feb 1, 1973·The American Journal of Physiology·R A NelsonP E Zollman
Nov 1, 1995·Journal of Applied Physiology·G C SieckJ F Watchko
Jul 25, 1998·Physiological Zoology·D B TinkerT D Beck
Feb 27, 1999·Current Opinion in Cell Biology·C C GregorioS Labeit
Nov 24, 1999·Journal of Applied Physiology·Y OhiraV R Edgerton
Jan 12, 2001·Journal of Molecular Biology·A D LiversageJ Trinick
Mar 10, 2001·Nature·H J HarlowP A Iaizzo
Apr 12, 2001·Journal of Applied Physiology·B A TikunovL C Rome
Mar 16, 2002·Journal of Applied Physiology·Thierry TourselYvonne Mounier
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Jul 16, 2004·Doklady. Biochemistry and Biophysics·I M VikhlyantsevI B Kozlovskaya
Jun 8, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bryan C RourkeVincent J Caiozzo
Aug 10, 2006·Journal of Muscle Research and Cell Motility·Martina Krüger, Wolfgang A Linke
Mar 29, 2007·Physiological and Biochemical Zoology : PBZ·T D LohuisP A Iaizzo
Jan 5, 2008·Physiological and Biochemical Zoology : PBZ·John D HersheyDavid C Lin
May 27, 2008·American Journal of Physiology. Heart and Circulatory Physiology·O Lynne NelsonHenk Granzier
Mar 1, 2012·Frontiers in Physiology·Coen A C OttenheijmSiegfried Labeit
Feb 6, 2013·Biochemistry. Biokhimii︠a︡·I M Vikhlyantsev, Z A Podlubnaya
Jan 1, 2014·Frontiers in Physiology·Logan C Meyer, Nathan T Wright
Mar 15, 2014·Circulation Research·Wolfgang A Linke, Nazha Hamdani
Jun 18, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Chen-Xi YangNandu Goswami

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Citations

Dec 7, 2018·Journal of Applied Physiology·Johanna K Freundt, Wolfgang A Linke
Jul 30, 2020·Ecology and Evolution·Enrique González-BernardoVincenzo Penteriani
May 31, 2017·Biophysics Reviews·Ivan M Vikhlyantsev, Zoya A Podlubnaya
Mar 9, 2021·Frontiers in Physiology·Fabrice BertileSylvain Giroud

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