Seasonal changes in markers of oxidative damage to lipids and DNA; correlations with seasonal variation in diet

Mutation Research
B SmolkováAndrew Collins

Abstract

We have addressed the question whether the relatively high incidence of cardiovascular disease and certain cancers in countries of central/eastern Europe might be associated with nutritional imbalance, in particular a lack of fresh fruit and vegetables in the diet in winter months. Nutritional parameters and markers of oxidative stress were studied in three Slovak population groups: 46 survivors of myocardial infarction (MI group) and 48 healthy, normolipidemic subjects (NL), living in or near Bratislava; and 70 rural controls (RC group) living a more traditional life style in a country town. Data were collected in February/March and September/October of two consecutive years, representing times of minimum and maximum local availability of fresh fruits and vegetables. Oxidative stress was monitored using two biomarkers; plasma malondialdehyde (MDA, a product of lipid peroxidation), and oxidation of lymphocyte DNA. Dietary antioxidants, folic acid, homocysteine, total antioxidant status (FRAP) and uric acid were measured in plasma. Food frequency questionnaires were administered. Vegetable consumption in summer/autumn was twice as high as in winter/spring. DNA damage did not vary consistently across the seasons. Mean plasma MDA ...Continue Reading

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Citations

Jun 24, 2008·Ethnicity & Health·Timothy Adrian JinamJuli Edo
Jan 22, 2010·European Journal of Public Health·Laura PaalanenTiina Laatikainen
Apr 22, 2010·Neurological Research·Asterios KaragiannisVasilios G Athyros
Nov 28, 2008·Electromagnetic Biology and Medicine·Francesco RaggiRuggero Rossi
Sep 15, 2009·The Science of the Total Environment·Wei-Te WuTrong-Neng Wu
Nov 19, 2015·The Science of the Total Environment·Jun YangQiyong Liu
Dec 24, 2008·Journal of the American Dietetic Association·Emily LockeAlan Kuniyuki
Jul 1, 2004·Mutation Research·Andrew R Collins, Lynnette R Ferguson
Aug 23, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrew R Collins
May 5, 2006·Environmental and Molecular Mutagenesis·Andrés BendeskyPatricia Ostrosky-Wegman
Apr 30, 2005·Nutrition and Cancer·Cynthia A ThomsonJohn P Pierce
Aug 10, 2018·Nutrition Research and Practice·Nesli ErsoyNeslişah Rakicioğlu

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