Seasonal fluctuations in serum levels of vitamin D in Japanese patients with multiple sclerosis.

Journal of Neuroimmunology
Masaaki NiinoSeiji Kikuchi

Abstract

We explored the presence of seasonal fluctuations in serum vitamin D levels and potential relationship between vitamin D levels and disease severity or prognosis in patients with multiple sclerosis (MS) in northern Japan. Serum levels of 25(OH)D in spring were significantly lower than in summer and autumn, whereas no differences in 1,25(OH)2D levels were demonstrated among four seasons. Seasonal fluctuations in 25(OH)D were demonstrated in patients with EDSS ≤3.5, but not in those with EDSS≥4.0. Negative correlations between 25(OH)D and EDSS or MSSS were found in each season. Seasonal fluctuations in 25(OH)D levels may be affected by physical disabilities.

References

Jun 13, 1998·The American Journal of Clinical Nutrition·S S Harris, B Dawson-Hughes
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Kassandra L MungerAlberto Ascherio
Mar 11, 2008·Annals of Epidemiology·Michael F Holick
Nov 7, 2008·Multiple Sclerosis : Clinical and Laboratory Research·M OsoegawaUNKNOWN Research Committee of Neuroimmunological Diseases
Nov 5, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Bianca Weinstock-GuttmanMurali Ramanathan
Jul 13, 2011·Journal of Epidemiology·Akiko NanriTetsuya Mizoue
Jun 16, 2012·Neurology·Alberto Ascherio, Ruth Ann Marrie
Jun 16, 2012·Neurology·Kristin I Løken-AmsrudKjell-Morten Myhr
Feb 12, 2015·Journal of Neuroimmunology·Masaaki NiinoJun-ichi Kira
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Jun 28, 2016·Biomedical Reports·Asako Maruyama-NagaoYoshio Suzuki
Jun 18, 2017·Multiple Sclerosis and Related Disorders·Charles Pierrot-Deseilligny, Jean-Claude Souberbielle
Nov 7, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H HouzenM Niino
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Mar 12, 2019·Journal of Autoimmunity·Erin Yamamoto, Trine N Jørgensen
Jul 5, 2019·CNS & Neurological Disorders Drug Targets·Javier Caballero-VillarrasoIsaac Túnez
Oct 5, 2019·Neurology. Neuroimmunology and Neuroinflammation·Xuan FengAnthony T Reder
Nov 7, 2019·CNS Drugs·Joost SmoldersTrygve Holmøy
Jan 16, 2020·Neurology. Neuroimmunology and Neuroinflammation·Benjamin M JacobsRuth Dobson
Mar 12, 2020·Frontiers in Neurology·Priscilla Bäcker-KoduahFriedemann Paul
Dec 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Patrick OstkampUNKNOWN German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network
Feb 27, 2021·Multiple Sclerosis and Related Disorders·Kristin WesnesKjetil Bjørnevik

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