Seasonal influenza immunisation: Strategies for older adults

International Journal of Clinical Practice
William SchaffnerAlbert D M E Osterhaus

Abstract

Adults over the age of 60-65 years suffer disproportionally from seasonal influenza, experiencing high rates of complications, exacerbation of underlying medical comorbidities, and excess mortality. Thus, older adults are an important priority for influenza immunisation campaigns. Unfortunately, older adults generally display lower immune responses to standard influenza vaccines because of immunosenescence, with resulting suboptimal vaccine effectiveness. Thus, the development of improved vaccines that heighten immune responses and improve effectiveness is an important medical need. To this end, enhanced influenza vaccines specifically targeting this age group have been developed, which seek to overcome the inherent limitations in the immune responses of older adults. Both the licensed high-dose trivalent influenza vaccine (hdTIV) containing fourfold higher antigen contents than standard vaccine, and the MF59® -adjuvanted trivalent influenza vaccine (aTIV) have been proven to be safe and well-tolerated while enhancing the immune response. Healthcare providers for populations of older adults should be advised to routinely use these enhanced influenza vaccines in seasonal immunisation campaigns to provide improved immunity agains...Continue Reading

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Citations

May 15, 2020·The Journal of Infectious Diseases·Benjamin J CowlingA Danielle Iuliano
Jul 22, 2020·Human Vaccines & Immunotherapeutics·Ke ZhangJunqiong Huang
Aug 14, 2020·Deutsche medizinische Wochenschrift·Anja KwetkatHans Jürgen Heppner
Jul 28, 2019·Aging Clinical and Experimental Research·Jessica Bartoszko, Mark Loeb
Dec 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin J CowlingMark G Thompson
Nov 6, 2020·Vaccines·Rossella CianciGiovanni Gambassi
Feb 12, 2020·Human Vaccines & Immunotherapeutics·Mera AbabnehFaris Ababneh
Mar 31, 2021·Geriatric Nursing·Barbara Resnick
May 26, 2021·MMW Fortschritte der Medizin·Anja KwetkatAndreas H Leischker
Jul 9, 2021·Der Internist·Anja KwetkatAndreas Leischker
Oct 1, 2021·The Journal of Infectious Diseases·Tanja BeckerAlbert D M E Osterhaus

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