Seasonal influenza vaccine in immunocompromised persons

Human Vaccines & Immunotherapeutics
Mohammad Bosaeed, Deepali Kumar

Abstract

Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. In this review, we discuss the impact of influenza infection and evidence for vaccine effectiveness and immunogenicity. Overall, lower respiratory disease from influenza is common; however, vaccine immunogenicity is low. Despite this, in some populations, influenza vaccine has demonstrated effectiveness in reducing severe disease. Various strategies to improve influenza vaccine immunogenicity have been attempted including two vaccine doses in the same influenza season, intradermal, adjuvanted, and high-dose vaccines. The timing of influenza vaccine is also important to achieve optimal immunogenicity. Given the suboptimal immunogenicity, family members and healthcare professionals involved in the care of these populations should be vaccinated. Health care professional recommendation for vaccination is an important factor in vaccine coverage.

References

May 1, 1995·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L S EltingG P Bodey
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M YousufE Whimbey
Oct 20, 1998·Australian and New Zealand Journal of Medicine·S SchepetiukM Qiao
Feb 7, 2002·The European Respiratory Journal·P J MazzoneJ R Maurer
Jul 5, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Regis A VilchezShimon Kusne
Oct 13, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adeyemi LawalThomas D Schiano
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gaia MagnaniAngelo Branzi
Sep 20, 2005·Bone Marrow Transplantation·C M MachadoC S Pannuti
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ManuelD Kumar
Nov 23, 2007·Immunity·Amy S McKeePhilippa Marrack
Dec 29, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ScharpéW E Peetermans
Jan 30, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N KhannaH H Hirsch
Feb 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kelly A BirdwellPeter F Wright
Feb 10, 2009·Vaccine·Elaine TrittoEnnio De Gregorio
Feb 28, 2009·Current Opinion in Immunology·Bart N LambrechtHamida Hammad
Jun 30, 2009·The Pediatric Infectious Disease Journal·Timo VesikariAudino Podda
Jul 14, 2010·The Lancet Infectious Diseases·Deepali KumarUNKNOWN American Society of Transplantation H1N1 Collaborative Study Group
Jan 21, 2011·The Pediatric Infectious Disease Journal·Iva HojsakRivka Shapiro
Mar 8, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oriol ManuelDeepali Kumar
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I KaterinisJ Villard
Aug 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E CorderoP Perez-Romero
Aug 17, 2011·Immunology and Cell Biology·Yoichi Furuya
Sep 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A SchafferH J Ross
Oct 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarUNKNOWN AST Infectious Diseases Community of Practice
Oct 11, 2011·The Pediatric Infectious Disease Journal·Steven BlackRino Rappuoli
Oct 29, 2011·The Lancet Infectious Diseases·Michael T OsterholmEdward A Belongia
May 1, 2012·Antiviral Therapy·Claire-Anne SiegristUNKNOWN H1N1 study group
Aug 21, 2012·The Journal of Infectious Diseases·Charles R BeckJonathan S Nguyen-Van-Tam
Sep 4, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicole A KarrasMichael R Verneris
Sep 25, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T FairheadD Kumar
Oct 20, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Perez-RomeroE Cordero
Feb 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A BaluchD Kumar
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Danziger-IsakovUNKNOWN AST Infectious Diseases Community of Practice
Jun 4, 2013·Virus Research·Mariana BazKanta Subbarao
Nov 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J MemoliJeffery K Taubenberger
Jan 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America

❮ Previous
Next ❯

Citations

Jul 8, 2020·Antimicrobial Agents and Chemotherapy·Bindumadhav M MaratheElena A Govorkova
Jul 24, 2020·Expert Review of Vaccines·Mario Rivera-IzquierdoJosé Luis Barranco-Quintana
Aug 18, 2020·Journal of Immunology Research·Andrés NoéEleanor Barnes
Aug 18, 2020·International Journal of Nephrology and Renovascular Disease·Intissar Haddiya
Nov 26, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mayla SgrullettiViviana Moschese
Jan 23, 2021·Clinical Journal of Oncology Nursing·Ellen Carr
Jan 24, 2021·Journal of General Internal Medicine·Jessica R CataldiAllison Kempe
Mar 10, 2021·Infectious Diseases and Therapy·Elda RighiEvelina Tacconelli
May 25, 2021·Current Treatment Options in Infectious Diseases·Tara M Babu, Camille N Kotton
Jul 31, 2021·Frontiers in Immunology·Jidang ChenHinh Ly
Aug 7, 2021·Vaccines·Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Deepali KumarAST Infectious Diseases Community of Practice
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Pearlie P ChongDavid J Weber
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ru-Chien ChiKathleen M Neuzil
© 2022 Meta ULC. All rights reserved