Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial

Lancet
Badara CisseJean-François Trape

Abstract

In the Sahel and sub-Sahelian regions of Africa, malaria transmission is highly seasonal. During a short period of high malaria transmission, mortality and morbidity are high in children under age 5 years. We assessed the efficacy of seasonal intermittent preventive treatment-a full dose of antimalarial treatment given at defined times without previous testing for malaria infection. We did a randomised, placebo-controlled, double-blind trial of the effect of intermittent preventive treatment on morbidity from malaria in three health-care centres in Niakhar, a rural area of Senegal. 1136 children aged 2-59 months received either one dose of artesunate plus one dose of sulfadoxine-pyrimethamine or two placebos on three occasions during the malaria transmission season. The primary outcome was a first or single episode of clinical malaria detected through active or passive case detection. Primary analysis was by intention-to-treat. This study is registered with , number NCT00132561. During 13 weeks of follow-up, the intervention led to an 86% (95% CI 80-90) reduction in the occurrence of clinical episodes of malaria. With passive case detection, protective efficacy against malaria was 86% (77-92), and when detected actively was 86%...Continue Reading

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Citations

Aug 21, 2013·Trends in Parasitology·Meera VenkatesanChristopher V Plowe
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Denis BoulangerFrancois Simondon
Mar 7, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mary J HamelLaurence Slutsker
Apr 18, 2013·Asian Pacific Journal of Tropical Biomedicine·Kwabena Obeng DueduTheophilus Adiku
Nov 10, 2006·The New England Journal of Medicine·Miriam K LauferChristopher V Plowe
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robin KobbeJürgen May
Sep 26, 2013·International Journal of Epidemiology·Valerie DelaunayCheikh Sokhna
Jan 13, 2012·The Journal of Infectious Diseases·Jean-François TrapeJean-François Molez
Nov 30, 2006·The Pediatric Infectious Disease Journal·Avinash K Shetty, Charles R Woods
May 31, 2007·Journal of Paediatrics and Child Health·Sally Munday
Nov 22, 2007·Annals of Tropical Medicine and Parasitology·B Walther, M Walther
Feb 20, 2007·Malaria Journal·Andrew VallelyDaniel Chandramohan
Jun 7, 2007·Malaria Journal·Sylvie CornelieFrancois Simondon
Sep 30, 2009·Malaria Journal·Seth Owusu-AgyeiDaniel Chandramohan
Dec 5, 2009·Malaria Journal·Arantxa Roca-FeltrerIlona Carneiro
Oct 3, 2006·PLoS Clinical Trials·Samuel DunyoMargaret Pinder
Jan 27, 2007·PLoS Medicine·Marc LipsitchBruce R Levin

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