Seasonal pattern of early mortality and infectious complications in liver transplant recipients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
N SinghT Gayowski

Abstract

Seasonal variation has been documented in the frequency and attributable mortality of a number of medical illnesses and infections in the nontransplantation setting. Whether similar trends exist in transplant recipients is not known. Seasonal rates of overall and early mortality and contributory variables stratified by season were assessed in 190 consecutive liver transplant recipients who underwent transplantation over a 10-year period. The frequency of infectious complications and rejection was also assessed and stratified by season of transplantation. Early (deaths occurring in the first year posttransplantation), but not overall, mortality correlated significantly with seasonality. Of patients with early mortality, 43% (13 of 30 patients) died in winter; 23% (7 of 30 patients), in spring; 13% (4 of 30 patients), in summer; and 20% (6 of 30 patients), in fall. The frequency of deaths in winter was significantly greater than for all other seasons (P = .022). The high wintertime mortality could not be explained by previously recognized risk factors portending a poor outcome, e.g., United Network for Organ Sharing status, Child-Pugh score, surgical time, blood loss, pretransplantation and posttransplantation dialysis, infection...Continue Reading

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Citations

Dec 13, 2006·Journal of Gastroenterology·Shi-Jun ZhangYan-Li Gu
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina Singh
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kashif RazaShahid Husain
Jan 20, 2007·Heart & Lung : the Journal of Critical Care·Burke A CunhaVitaliy Krol
Sep 27, 2005·Transplantation Proceedings·S FaenzaA Pinna
Feb 7, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Zsuzsanna KovatsVeronika Müller
May 5, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·William GelsonGraeme J M Alexander

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