Abstract
Neurological manifestations secondary to extrapontine myelinolysis and rhabdomyolysis caused by hypernatremia are infrequently reported. Occurrence of neurological manifestations due to spontaneous hypernatremia during postpartum period producing rhabdomyolysis and cerebral parenchymal MRI changes has not been previously reported. Evaluation of clinical and radiological profile of postpartum hypernatremia. Clinical, laboratory and radiological data of eleven women in postpartum period presenting with hypernatremic encephalopathy with or without muscle weakness were reviewed. Eleven puerperal women presented with encephalopathy due to hypernatremia from 2007 to 2009. Consciousness was altered in all the patients ranging from confusion to deep coma. Nine patients had quadriparesis, eight had corticospinal and corticobulbar dysfunction, six had ataxia, and seizures occurred in four patients. The patients had hypernatremia ranging from 158 to 199mEq/l with hyperchloremia, markedly elevated serum CK levels (2572 to 61,107U) and azotemia. Ten patients underwent MRI which revealed hyperintensity of corpus callosum in all the patients in T2, FLAIR and diffusion weighted sequences. Symmetrical hyperintensities were seen also in internal...Continue Reading
References
Aug 1, 1974·The Journal of Pediatrics·M S Blank, P B Farnsworth
Dec 29, 1994·The New England Journal of Medicine·K T Kim
Jan 1, 1996·Journal of Neuropathology and Experimental Neurology·A SoupartG Decaux
Nov 15, 1996·Annals of Internal Medicine·M L Moritz
Apr 24, 1999·Neurology·R BakshiP R Kinkel
May 18, 2000·The New England Journal of Medicine·H J Adrogué, N E Madias
Nov 20, 2002·Journal of Computer Assisted Tomography·Ritsuyo KobataMitsufumi Mayumi
Feb 9, 2005·Experimental Neurology·Yoshihisa SugimuraYoshiharu Murata
Feb 9, 2005·Neurology·Annette H M van der Helm-van MilHubertus I J Harinck
Jun 14, 2006·Journal of Critical Care·Venkatesh AiyagariMichael N Diringer
Sep 13, 2006·Neurology·Takeshi Machino, Toshihiro Yoshizawa
Jan 5, 2007·Indian Journal of Pediatrics·Faruk IncecikSakir Altunbasak
Mar 27, 2007·Clinical and Experimental Nephrology·Sanjay VikrantAshok Sharma
Feb 13, 2008·Archives of Neurology·Vivien H LeeAlejandro A Rabinstein
Jul 1, 2009·Neurology·Tamika M BurrusAlejandro A Rabinstein
Citations
Feb 8, 2013·Acta neurologica Belgica·Sanjay DixitChris Rowland-Hill
Jun 12, 2010·Current Opinion in Nephrology and Hypertension·Richard H SternsStephen Silver
Dec 21, 2012·International Journal of Rheumatic Diseases·Tien Eang CheahSargunan Sockalingam
May 19, 2012·BMJ Case Reports·Ines RegoJorge Resende Pereira
Aug 28, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mohamed Osama Hegazi, Anant Mashankar
Dec 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kenan TurgutalpAhmet Kiykim
Dec 18, 2013·Annals of Indian Academy of Neurology·Karkal Ravishankar NaikGayatri Narayanappa
Oct 29, 2011·Neurologic Clinics·Michael J Angel, G Bryan Young
Dec 22, 2015·Internal and Emergency Medicine·Ihsan AtesFatih Dede
May 11, 2013·Parkinsonism & Related Disorders·Aaron de Souza
Apr 15, 2014·BMC Endocrine Disorders·Giovanni CoronaAlessandro Peri
Feb 16, 2013·AJNR. American Journal of Neuroradiology·F Y IsmailM Ljubisavljevic
Jan 7, 2017·The Neuroradiology Journal·A ChhabraD Goel
Jul 7, 2017·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Lucía Dieste-PérezTijs J Tobias
Aug 5, 2015·Electrolyte & Blood Pressure : E & BP·Min Jee HanMoon Ki Hong
Nov 3, 2017·Pediatric Emergency Care·Eike BlohmKavita Babu
Oct 27, 2011·Current Opinion in Critical Care·Milap Pokaharel, Clay A Block
Oct 20, 2018·Pituitary·Roxana Maria Tudor, Christopher J Thompson
Jun 29, 2021·International Medical Case Reports Journal·Shoko NiidaIchiro Takeuchi
Sep 21, 2021·Internal Medicine Journal·Ananthu NarayanNaveet Wig