Seasonal tracking of histo-blood group antigen expression and norovirus binding in oyster gastrointestinal cells

Journal of Food Protection
Peng TianRobert Mandrell

Abstract

Noroviruses (NORs) are the most common cause of viral gastroenteritis outbreaks. Outbreaks are often associated with the consumption of contaminated oysters and generally occur between the months of November and March, when oysters produce the highest levels of glycogen. Oyster glycogen has been proposed as playing a role in NOR accumulation. Recent research indicates that histo-blood group antigens (HBGAs) function as viral receptors on human gastrointestinal cells. In this study, oyster glycogen was tested to determine whether it contains HBGA-like molecules and whether it plays a role in NOR binding. The correlation between the amount of HBGA expression and NOR binding also was measured. We also tested whether seasonal changes affected HBGA expression and binding of recombinant NORs. The results indicate that recombinant NOR binding is highly correlated with HBGA expression in Virginica (Crassostrea virginica), Pacific (Crassostrea gigas), and Kumamato (Crassostrea sikamea) oysters, but the association does not have a seasonal pattern. No obvious trend in either HBGA expression or recombinant NOR binding by month was noted. A significant increase in recombinant NOR binding was observed in Virginica and Pacific oysters in a s...Continue Reading

References

Jan 1, 1977·Applied and Environmental Microbiology·R Di GirolamoJ Matches
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Apr 1, 2000·Applied and Environmental Microbiology·W Burkhardt, K R Calci
Aug 27, 2002·Emerging Infectious Diseases·Gregory D EbelLaura D Kramer
May 19, 2006·Emerging Infectious Diseases·Françoise Le GuyaderJacques Le Pendu
Nov 7, 2006·Letters in Applied Microbiology·P TianR E Mandrell
Nov 8, 2006·Journal of Clinical Microbiology·Françoise S Le GuyaderFranco M Ruggeri

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Citations

Nov 15, 2018·Food and Environmental Virology·Laetitia KaasJérémie Langlet
Apr 30, 2017·Food and Environmental Virology·Elisabetta SuffrediniDario De Medici
Aug 14, 2009·Journal of Applied Microbiology·C McLeodD Day
Jun 22, 2010·Applied and Environmental Microbiology·Haifa MaaloufFrançoise S Le Guyader
May 31, 2015·Applied and Environmental Microbiology·Najoua DrouazFrançoise S Le Guyader
Jan 30, 2015·Food and Environmental Virology·Jérémie LangletGail Greening

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